Technology Process of methyl 4-((2,2-difluorocyclonon-3-ynyl)methyl)benzoate
There total 7 articles about methyl 4-((2,2-difluorocyclonon-3-ynyl)methyl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at 0 ℃;
for 0.666667h;
DOI:10.1021/ol500260d
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: caesium carbonate / acetonitrile / 0.5 h / 20 °C
1.2: 2 h / 0 - 20 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0 °C
3.1: 20% palladium hydroxide-activated charcoal; hydrogen / ethanol / 1.5 h
4.1: trimethylaluminum / dichloromethane; toluene / 0.17 h / -78 °C
4.2: 8 h / 20 °C
5.1: trimethylaluminum / dichloromethane; toluene / 0.17 h / -78 °C
5.2: 8 h / 20 °C
6.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / -78 °C
6.2: -78 - 20 °C
7.1: lithium diisopropyl amide / tetrahydrofuran / 0.67 h / 0 °C
With
20% palladium hydroxide-activated charcoal; hydrogen; trimethylaluminum; potassium hexamethylsilazane; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile;
2.1: |Wittig Olefination;
DOI:10.1021/ol500260d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0 °C
2.1: 20% palladium hydroxide-activated charcoal; hydrogen / ethanol / 1.5 h
3.1: trimethylaluminum / dichloromethane; toluene / 0.17 h / -78 °C
3.2: 8 h / 20 °C
4.1: trimethylaluminum / dichloromethane; toluene / 0.17 h / -78 °C
4.2: 8 h / 20 °C
5.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / -78 °C
5.2: -78 - 20 °C
6.1: lithium diisopropyl amide / tetrahydrofuran / 0.67 h / 0 °C
With
20% palladium hydroxide-activated charcoal; hydrogen; trimethylaluminum; potassium hexamethylsilazane; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane; toluene;
1.1: |Wittig Olefination;
DOI:10.1021/ol500260d
