methyl [(2S,3R,E)-3-acetoxy-1-[(1S,2R)-2-(tert-butyldimethylsiloxy)-1,2-diphenylethyl]-2-methyl-2,3,4,6,7,8-hexahydroquinolin-5(1H)ylidene]acetate

Base Information

Chemical Name:methyl [(2S,3R,E)-3-acetoxy-1-[(1S,2R)-2-(tert-butyldimethylsiloxy)-1,2-diphenylethyl]-2-methyl-2,3,4,6,7,8-hexahydroquinolin-5(1H)ylidene]acetate
CAS No.:1072157-55-1
Molecular Formula:C₃₅H₄₇NO₅Si
Molecular Weight:589.847
Hs Code.:

Synonyms:methyl [(2S,3R,E)-3-acetoxy-1-[(1S,2R)-2-(tert-butyldimethylsiloxy)-1,2-diphenylethyl]-2-methyl-2,3,4,6,7,8-hexahydroquinolin-5(1H)ylidene]acetate

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Chemical Property of methyl [(2S,3R,E)-3-acetoxy-1-[(1S,2R)-2-(tert-butyldimethylsiloxy)-1,2-diphenylethyl]-2-methyl-2,3,4,6,7,8-hexahydroquinolin-5(1H)ylidene]acetate

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Technology Process of methyl [(2S,3R,E)-3-acetoxy-1-[(1S,2R)-2-(tert-butyldimethylsiloxy)-1,2-diphenylethyl]-2-methyl-2,3,4,6,7,8-hexahydroquinolin-5(1H)ylidene]acetate

There total 2 articles about methyl [(2S,3R,E)-3-acetoxy-1-[(1S,2R)-2-(tert-butyldimethylsiloxy)-1,2-diphenylethyl]-2-methyl-2,3,4,6,7,8-hexahydroquinolin-5(1H)ylidene]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1072157-63-1
C₃₂H₄₃NO₃SSi

: 96-32-2
bromoacetic acid methyl ester

: 1072157-55-1
methyl [(2S,3R,E)-3-acetoxy-1-[(1S,2R)-2-(tert-butyldimethylsiloxy)-1,2-diphenylethyl]-2-methyl-2,3,4,6,7,8-hexahydroquinolin-5(1H)ylidene]acetate

Guidance literature:: C₃₂H₄₃NO₃SSi; bromoacetic acid methyl ester; In tetrahydrofuran; at 20 ℃; for 11h;

With triethylamine; triphenylphosphine; In acetonitrile; at 20 ℃; Reflux; Inert atmosphere;
DOI:10.1021/ol802068q

Reference yield:

: C₃₅H₄₇NO₅SSi

: 1072157-55-1
methyl [(2S,3R,E)-3-acetoxy-1-[(1S,2R)-2-(tert-butyldimethylsiloxy)-1,2-diphenylethyl]-2-methyl-2,3,4,6,7,8-hexahydroquinolin-5(1H)ylidene]acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; triphenylphosphine; In acetonitrile; for 3h; Inert atmosphere; Reflux;
DOI:10.1055/s-0029-1216920

Reference yield:

: 1072157-55-1
methyl [(2S,3R,E)-3-acetoxy-1-[(1S,2R)-2-(tert-butyldimethylsiloxy)-1,2-diphenylethyl]-2-methyl-2,3,4,6,7,8-hexahydroquinolin-5(1H)ylidene]acetate

: 1072157-56-2
methyl [(2S,3R,4aR,8aS)-3-acetoxy-1-[(1S,2R)-2-(tert-butyldimethylsiloxy)-1,2-diphenylethyl]-2-methyldecahydroquinolin-5-yl]acetate

: C₃₅H₅₁NO₅Si

Guidance literature:: With platinum(IV) oxide; hydrogen; In methanol; for 0.5h; under 775.743 Torr; optical yield given as %de;
DOI:10.1021/ol802068q