(S)-4-[[2-[4'-Fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl]ethynyl]methoxy-phosphinyl]-3-t-butyldiphenylsilyloxy-butanoic acid, methyl ester

Base Information

Chemical Name:(S)-4-[[2-[4'-Fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl]ethynyl]methoxy-phosphinyl]-3-t-butyldiphenylsilyloxy-butanoic acid, methyl ester
CAS No.:119900-77-5
Molecular Formula:C₃₉H₄₄FO₅PSi
Molecular Weight:670.833
Hs Code.:

Synonyms:(S)-4-[[2-[4'-Fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl]ethynyl]methoxy-phosphinyl]-3-t-butyldiphenylsilyloxy-butanoic acid, methyl ester

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Chemical Property of (S)-4-[[2-[4'-Fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl]ethynyl]methoxy-phosphinyl]-3-t-butyldiphenylsilyloxy-butanoic acid, methyl ester

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Technology Process of (S)-4-[[2-[4'-Fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl]ethynyl]methoxy-phosphinyl]-3-t-butyldiphenylsilyloxy-butanoic acid, methyl ester

There total 8 articles about (S)-4-[[2-[4'-Fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl]ethynyl]methoxy-phosphinyl]-3-t-butyldiphenylsilyloxy-butanoic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88759-56-2
(S)-bromo-3-hydroxybutyric acid methyl ester

: 119900-77-5
(S)-4-[[2-[4'-Fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl]ethynyl]methoxy-phosphinyl]-3-t-butyldiphenylsilyloxy-butanoic acid, methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: DMAP, imidazole / dimethylformamide

2: NaI / butan-2-one / Heating

3: 75 percent / 16 h / 150 - 160 °C

4: trimethylbromosilane (TMSBr) / CH₂Cl₂

5: pyridine / 20 h

6: CH₂Cl₂

7: oxalyl chloride, DMF / CH₂Cl₂

8: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) -78 deg C

With pyridine; 1H-imidazole; dmap; n-butyllithium; oxalyl dichloride; trimethylsilyl bromide; N,N-dimethyl-formamide; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00173a007

Reference yield:

: 119673-72-2
(S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

: 119900-77-5
(S)-4-[[2-[4'-Fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl]ethynyl]methoxy-phosphinyl]-3-t-butyldiphenylsilyloxy-butanoic acid, methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / 16 h / 150 - 160 °C

2: trimethylbromosilane (TMSBr) / CH₂Cl₂

3: pyridine / 20 h

4: CH₂Cl₂

5: oxalyl chloride, DMF / CH₂Cl₂

6: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) -78 deg C

With pyridine; n-butyllithium; oxalyl dichloride; trimethylsilyl bromide; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm00173a007

Reference yield:

: 119673-71-1
Methyl 3S-((t-butyl)diphenylsilyloxy)-4-bromo butanoate

: 119900-77-5
(S)-4-[[2-[4'-Fluoro-3,3',5-trimethyl-[1,1'-biphenyl]-2-yl]ethynyl]methoxy-phosphinyl]-3-t-butyldiphenylsilyloxy-butanoic acid, methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NaI / butan-2-one / Heating

2: 75 percent / 16 h / 150 - 160 °C

3: trimethylbromosilane (TMSBr) / CH₂Cl₂

4: pyridine / 20 h

5: CH₂Cl₂

6: oxalyl chloride, DMF / CH₂Cl₂

7: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) -78 deg C

With pyridine; n-butyllithium; oxalyl dichloride; trimethylsilyl bromide; N,N-dimethyl-formamide; sodium iodide; In dichloromethane; butanone;
DOI:10.1021/jm00173a007