ethyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

Base Information

• Chemical Name: ethyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate
• CAS No.: 1344997-79-0
• Molecular Formula: C₃₀H₃₇ClN₂O₃S
• Molecular Weight: 541.154
• Mol file: 1344997-79-0.mol

Synonyms:ethyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

Chemical Property of ethyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

There total 7 articles about ethyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-carbethoxypiperidine (1126-09-6) + [3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl] acetaldehyde (1260024-00-7) → ethyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate (1344997-79-0)

Guidance literature:

4-carbethoxypiperidine; [3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl] acetaldehyde; With sodium acetate; acetic acid; In ethanol; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

4-bromo-2-chloro-1-[(1-methylethyl)oxy]benzene (201849-21-0) → ethyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate (1344997-79-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 2 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

3.1: sodium acetate; bromine; acetic acid / 20 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

5.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 75 °C / Inert atmosphere

6.1: sodium acetate; acetic acid / ethanol / 0.5 h / 20 °C / Inert atmosphere

6.2: 20 °C

With hydrogenchloride; potassium phosphate; water; bromine; potassium acetate; sodium acetate; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; 2.1: Suzuki Coupling / 4.1: Suzuki Coupling;

Reference yield:

2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazole (1258440-38-8) → ethyl 1-{2-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate (1344997-79-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium acetate; bromine; acetic acid / 20 °C

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.25 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

3.1: hydrogenchloride; water / tetrahydrofuran / 3 h / 75 °C / Inert atmosphere

4.1: sodium acetate; acetic acid / ethanol / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 °C

With hydrogenchloride; potassium phosphate; water; bromine; sodium acetate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;

upstream raw materials:

4-carbethoxypiperidine

[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl] acetaldehyde

4-bromo-2-chloro-1-[(1-methylethyl)oxy]benzene

2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazole