benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride

Base Information

• Chemical Name: benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride
• CAS No.: 1027369-06-7
• Molecular Formula: C₁₉H₂₀N₄O₃*ClH
• Molecular Weight: 388.854
• Mol file: 1027369-06-7.mol

Synonyms:benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride

Chemical Property of benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride

There total 1 articles about benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl 4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylate (77716-15-5) → benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride (1027369-06-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 2h;

DOI:10.1021/ol502203y

Reference yield: 93.0%

benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride (1027369-06-7) + methyl chloroformate (79-22-1) → 4-[(4-methoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-1-methyl-1H-pyrrole-2-carboxylic acid benzyl ester (1027881-53-3)

Guidance literature:

benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride; With triethylamine; at 20 ℃; for 0.166667h; Inert atmosphere;

methyl chloroformate; at 20 ℃; for 0.75h; Inert atmosphere;

DOI:10.1002/anie.200705295

Reference yield: 91.0%

benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride (1027369-06-7) + 4-[(tert-butoxycarbonyl)amino]-1-methylimidazole-2-carboxylic acid (128293-64-1) → benzyl 4-(4-(4-((tert-butoxycarbonyl)amino)-1-methyl-1H-imidazole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate

Guidance literature:

4-[(tert-butoxycarbonyl)amino]-1-methylimidazole-2-carboxylic acid; With 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

benzyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1021/ol502203y

upstream raw materials:

benzyl 4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylate

Downstream raw materials:

4-[(4-methoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-1-methyl-1H-pyrrole-2-carboxylic acid benzyl ester