2-(hexyloxy)-1,3-dimethoxy-5-<4-(4-methyl-5-thiazolyl)but-1-enyl>benzene

Base Information

Chemical Name:2-(hexyloxy)-1,3-dimethoxy-5-<4-(4-methyl-5-thiazolyl)but-1-enyl>benzene
CAS No.:165685-94-9
Molecular Formula:C₂₂H₃₁NO₃S
Molecular Weight:389.559
Hs Code.:

Synonyms:2-(hexyloxy)-1,3-dimethoxy-5-<4-(4-methyl-5-thiazolyl)but-1-enyl>benzene

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Chemical Property of 2-(hexyloxy)-1,3-dimethoxy-5-<4-(4-methyl-5-thiazolyl)but-1-enyl>benzene

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Technology Process of 2-(hexyloxy)-1,3-dimethoxy-5-<4-(4-methyl-5-thiazolyl)but-1-enyl>benzene

There total 9 articles about 2-(hexyloxy)-1,3-dimethoxy-5-<4-(4-methyl-5-thiazolyl)but-1-enyl>benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 165685-93-8
3-(4-Methyl-thiazol-5-yl)-propionaldehyde

: <4-(hexyloxy)-3,5-dimethoxybenzyl>triphenylphosphonium bromide

: 165685-94-9
2-(hexyloxy)-1,3-dimethoxy-5-<4-(4-methyl-5-thiazolyl)but-1-enyl>benzene

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 21 ℃; for 72h; Yield given;
DOI:10.1021/jm00012a012

Reference yield:

: 137-00-8,8042-97-5
5-hydroxyethyl-4-methylthiazole

: 165685-94-9
2-(hexyloxy)-1,3-dimethoxy-5-<4-(4-methyl-5-thiazolyl)but-1-enyl>benzene

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 1.) from -10 deg C to 0 deg C, 2h, 2.) 21 deg C, 2 h

2: 18-crown-6 / dimethylformamide / 1.) 21 deg C, 16 h, 2.) 80 deg C, 1 h

3: 36 g / diisobutylaluminum hydride / toluene / 1 h / 21 °C

4: potassium tert-butoxide / tetrahydrofuran / 72 h / 21 °C

With 18-crown-6 ether; potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00012a012

Reference yield:

: 111-25-1
1-bromo-hexane

: 165685-94-9
2-(hexyloxy)-1,3-dimethoxy-5-<4-(4-methyl-5-thiazolyl)but-1-enyl>benzene

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / Bu₄NHSO₄, K₂CO₃ / toluene / 6 h / Heating

2: 95 percent / NaBH₄ / propan-2-ol / 2 h / 21 °C

3: 96 percent / HBr / CHCl₃ / 0.75 h / 5 °C

4: 90 percent / toluene / 3 h / Heating

5: potassium tert-butoxide / tetrahydrofuran / 72 h / 21 °C

With sodium tetrahydroborate; potassium tert-butylate; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In tetrahydrofuran; chloroform; isopropyl alcohol; toluene;
DOI:10.1021/jm00012a012