(S)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one

Base Information

Chemical Name:(S)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one
CAS No.:897931-55-4
Molecular Formula:C₂₈H₂₈N₂O₄
Molecular Weight:456.541
Hs Code.:

Synonyms:(S)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one

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Chemical Property of (S)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one

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Technology Process of (S)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one

There total 1 articles about (S)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 25902-89-0
4-methoxy-5-methyl-pyrimidin-2(1H)-one

: 65291-30-7
(R)-(+)-trityl glycidyl ether

: 897931-55-4
(S)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 - 80 ℃; for 19h;
DOI:10.1135/cccc20051465

Reference yield: 87.0%

: 897931-55-4
(S)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 897931-57-6
(S)-1-{2-[(diisopropoxyphosphoryl)methoxy]-3-(trityloxy)propyl}-4-methoxy-5-methylpyrimidin-2(1H)-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at -20 - 20 ℃;
DOI:10.1135/cccc20051465

Reference yield:

: 897931-55-4
(S)-1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxy-5-methylpyrimidin-2(1H)-one

: 913274-87-0
(S)-1-{2-[(diisopropoxyphosphoryl)methoxy]-3-(trityloxy)propyl}thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NaH / tetrahydrofuran / -20 - 20 °C

2: 4.0 g / SiO₂; Et₃N; H₂O / toluene; ethyl acetate

With water; silica gel; sodium hydride; triethylamine; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1135/cccc20051465