8--8-azabicyclo<4.2.0>oct-2-en-4-one

Base Information

Chemical Name:8--8-azabicyclo<4.2.0>oct-2-en-4-one
CAS No.:120230-13-9
Molecular Formula:C₂₃H₂₂N₂O₃S
Molecular Weight:406.505
Hs Code.:

8-<N-(phenylsulfonyl)tryptophyl>-8-azabicyclo<4.2.0>oct-2-en-4-one

Synonyms:8--8-azabicyclo<4.2.0>oct-2-en-4-one

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Chemical Property of 8--8-azabicyclo<4.2.0>oct-2-en-4-one

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Technology Process of 8--8-azabicyclo<4.2.0>oct-2-en-4-one

There total 6 articles about 8--8-azabicyclo<4.2.0>oct-2-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 120230-09-3,120328-40-7
8--8-aza-4-(1'-hydroxyethyl)-4-hydroxybicyclo<4.2.0>oct-2-ene

: 120230-13-9
8--8-azabicyclo<4.2.0>oct-2-en-4-one

Guidance literature:: With sodium periodate; In methanol; water; 1.) 0 deg C, 20 min, 2.) 25 deg C, 24 h;
DOI:10.1021/jo00273a024

Reference yield:

: 120230-11-7
2--7-endo-acetylisoquinuclidene

: 120230-13-9
8--8-azabicyclo<4.2.0>oct-2-en-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / potassium tert-butoxide, triethyl phosphite, O₂ / 2-methyl-propan-2-ol; 1,2-dimethoxy-ethane; CH₂Cl₂ / 3 h / -20 °C

2: 76 percent / NaBH₄ / methanol / 1 h / 0 °C

3: 53 percent / sodium periodate / methanol; H₂O / 1.) 0 deg C, 20 min, 2.) 25 deg C, 24 h

With sodium tetrahydroborate; sodium periodate; potassium tert-butylate; oxygen; triethyl phosphite; In methanol; 1,2-dimethoxyethane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo00273a024

Reference yield:

: 120230-10-6
2--7-endo-<1,1-(ethylenedioxy)ethyl>isoquinuclidene

: 120230-13-9
8--8-azabicyclo<4.2.0>oct-2-en-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / 10percent H₂SO₄, silica gel 60 / CH₂Cl₂ / 40 h / 25 °C

2: 79 percent / potassium tert-butoxide, triethyl phosphite, O₂ / 2-methyl-propan-2-ol; 1,2-dimethoxy-ethane; CH₂Cl₂ / 3 h / -20 °C

3: 76 percent / NaBH₄ / methanol / 1 h / 0 °C

4: 53 percent / sodium periodate / methanol; H₂O / 1.) 0 deg C, 20 min, 2.) 25 deg C, 24 h

With sodium tetrahydroborate; sodium periodate; sulfuric acid; potassium tert-butylate; oxygen; silica gel; triethyl phosphite; In methanol; 1,2-dimethoxyethane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo00273a024