O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine benzyl ester

Base Information

• Chemical Name: O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine benzyl ester
• CAS No.: 637779-90-9
• Molecular Formula: C₂₆H₂₇NO₇S
• Molecular Weight: 497.569
• Mol file: 637779-90-9.mol

Synonyms:O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine benzyl ester

Chemical Property of O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine benzyl ester

There total 2 articles about O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3(S)-hydroxy-2(S)-{[(4-methylphenyl)sulfonyl]amino}butanoic acid (43188-51-8) → O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine benzyl ester (637779-90-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / p-toluenesulfonic acid monohydrate / toluene / 12 h / Heating

2: 77 percent / pyridine / CH₂Cl₂ / 26 h / 20 °C

With pyridine; toluene-4-sulfonic acid; In dichloromethane; toluene;

DOI:10.1021/jo035379x

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine benzyl ester (637779-90-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / aq. NaOH / diethyl ether / 20 °C

2: 84 percent / p-toluenesulfonic acid monohydrate / toluene / 12 h / Heating

3: 77 percent / pyridine / CH₂Cl₂ / 26 h / 20 °C

With pyridine; sodium hydroxide; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; toluene;

DOI:10.1021/jo035379x

Reference yield: 100.0%

O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine benzyl ester (637779-90-9) → O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine (637779-45-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 16h;

DOI:10.1021/jo035379x

upstream raw materials:

3(S)-hydroxy-2(S)-{[(4-methylphenyl)sulfonyl]amino}butanoic acid

p-toluenesulfonyl chloride

Downstream raw materials:

O-(4-methoxybenzoyl)-N-tosyl-(L)-allo-threonine