(1S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-cyclobutanecarboxylic acid

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Chemical Name:(1S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-cyclobutanecarboxylic acid
CAS No.:566193-50-8
Molecular Formula:C₂₄H₃₂O₃Si
Molecular Weight:396.602
Hs Code.:

Synonyms:(1S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-cyclobutanecarboxylic acid

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Chemical Property of (1S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-cyclobutanecarboxylic acid

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Technology Process of (1S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-cyclobutanecarboxylic acid

There total 1 articles about (1S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 528560-23-8
methyl (1S,3R)-3-tert-butyldiphenylsilyloxymethyl-2,2-dimethylcyclobutane-1-carboxylate

: 566193-50-8
(1S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-cyclobutanecarboxylic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/S0957-4166(02)00749-8

Reference yield: 90.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 566193-50-8
(1S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-cyclobutanecarboxylic acid

: 528560-23-8
methyl (1S,3R)-3-tert-butyldiphenylsilyloxymethyl-2,2-dimethylcyclobutane-1-carboxylate

Guidance literature:: In diethyl ether;
DOI:10.1016/S0957-4166(02)00749-8

Reference yield:

: 566193-50-8
(1S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-cyclobutanecarboxylic acid

: 528560-25-0
methyl (1'S,3'S)-2-N-benzyloxycarbonylamino-3-(2',2'-dimethyl-3'-methoxycarbonylcyclobutyl)-(Z)-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / diethyl ether

2: 80 percent / n-Bu₄NF / tetrahydrofuran / 0.5 h / 20 °C

3: PDC / CH₂Cl₂ / 6 h / 20 °C

4: t-BuOK / CH₂Cl₂ / 64 h / -78 - 20 °C

With dipyridinium dichromate; potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; dichloromethane; 4: Wadsworth-Emmons condensation;
DOI:10.1016/S0957-4166(02)00749-8