5-bromo-2-(2-(tert-butyldimethylsilyloxy)ethoxy)benzaldehyde

Base Information

• Chemical Name: 5-bromo-2-(2-(tert-butyldimethylsilyloxy)ethoxy)benzaldehyde
• CAS No.: 949027-49-0
• Molecular Formula: C₁₅H₂₃BrO₃Si
• Molecular Weight: 359.335
• Mol file: 949027-49-0.mol

Synonyms:5-bromo-2-(2-(tert-butyldimethylsilyloxy)ethoxy)benzaldehyde

Chemical Property of 5-bromo-2-(2-(tert-butyldimethylsilyloxy)ethoxy)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-bromo-2-(2-(tert-butyldimethylsilyloxy)ethoxy)benzaldehyde

There total 1 articles about 5-bromo-2-(2-(tert-butyldimethylsilyloxy)ethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(tert-butyldimethylsilyloxy)ethyl bromide (86864-60-0) + 5-bromosalicyclaldehyde (1761-61-1) → 5-bromo-2-(2-(tert-butyldimethylsilyloxy)ethoxy)benzaldehyde (949027-49-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

Reference yield:

5-bromo-2-(2-(tert-butyldimethylsilyloxy)ethoxy)benzaldehyde (949027-49-0) → 2-(4-bromo-2-(cyclopenta-2,4-dienylidenemethyl)phenoxy)ethanol (1351600-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyrrolidine / methanol / 2 h / 20 °C / Inert atmosphere

2: pyridinium p-toluenesulfonate / methanol / 19 h / 20 °C / Inert atmosphere

With pyrrolidine; pyridinium p-toluenesulfonate; In methanol;

DOI:10.1021/ja108516b

Reference yield:

5-bromo-2-(2-(tert-butyldimethylsilyloxy)ethoxy)benzaldehyde (949027-49-0) → 2-(4-bromo-2-(cyclopenta-2,4-dienylidenemethyl)phenoxy)acetaldehyde (1351600-44-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyrrolidine / methanol / 2 h / 20 °C / Inert atmosphere

2: pyridinium p-toluenesulfonate / methanol / 19 h / 20 °C / Inert atmosphere

3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

With pyrrolidine; pyridinium p-toluenesulfonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; dimethyl sulfoxide;

DOI:10.1021/ja108516b

upstream raw materials:

2-(tert-butyldimethylsilyloxy)ethyl bromide

5-bromosalicyclaldehyde

Downstream raw materials:

2-(4-bromo-2-(cyclopenta-2,4-dienylidenemethyl)phenoxy)ethanol

2-(4-bromo-2-(cyclopenta-2,4-dienylidenemethyl)phenoxy)acetaldehyde