Technology Process of 3-fluorophenyl ethyl ketene
There total 3 articles about 3-fluorophenyl ethyl ketene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N-dimethyl-ethanamine;
In
tetrahydrofuran;
at 0 ℃;
for 16.1667h;
Inert atmosphere;
DOI:10.1021/ja300799t
- Guidance literature:
-
Multi-step reaction with 2 steps
1: thionyl chloride / dichloromethane / 15 h / 20 °C / Inert atmosphere
2: N,N-dimethyl-ethanamine / tetrahydrofuran / 16.17 h / 0 °C / Inert atmosphere
With
thionyl chloride; N,N-dimethyl-ethanamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja300799t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2.33 h / 0 °C / Inert atmosphere
1.2: 0 - 22 °C / Inert atmosphere
2.1: thionyl chloride / dichloromethane / 15 h / 20 °C / Inert atmosphere
3.1: N,N-dimethyl-ethanamine / tetrahydrofuran / 16.17 h / 0 °C / Inert atmosphere
With
n-butyllithium; thionyl chloride; N,N-dimethyl-ethanamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja300799t
