C₁₈H₁₃ClN₂S

Base Information

• Chemical Name: C₁₈H₁₃ClN₂S
• CAS No.: 1338597-03-7
• Molecular Formula: C₁₈H₁₃ClN₂S
• Molecular Weight: 324.834
• Mol file: 1338597-03-7.mol

Synonyms:C₁₈H₁₃ClN₂S

Chemical Property of C₁₈H₁₃ClN₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₃ClN₂S

There total 3 articles about C₁₈H₁₃ClN₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

propargyl bromide (106-96-7) + 2-amino-4-(p-chlorophenyl)-5-phenylthiazole → C18H13ClN2S (1338597-03-7)

Guidance literature:

With potassium carbonate; In toluene; at 20 ℃; for 8h; Inert atmosphere; Reflux;

DOI:10.1002/jhet.1674

Reference yield:

2-bromo-1-(4-chlorophenyl)-2-phenylethanone (1889-78-7) → C18H13ClN2S (1338597-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 8 h / Reflux

2: potassium carbonate / toluene / 8 h / 110 °C / Inert atmosphere

With potassium carbonate; In ethanol; toluene;

DOI:10.1002/jhet.638

Reference yield:

4'-chloro-2-phenylacetophenone (1889-71-0) → C18H13ClN2S (1338597-03-7)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine; acetic acid / chloroform / 20 °C

2: ethanol / 8 h / Reflux

3: potassium carbonate / toluene / 8 h / 110 °C / Inert atmosphere

With bromine; potassium carbonate; acetic acid; In ethanol; chloroform; toluene;

DOI:10.1002/jhet.638

upstream raw materials:

2-bromo-1-(4-chlorophenyl)-2-phenylethanone

propargyl bromide

4'-chloro-2-phenylacetophenone

Downstream raw materials:

[4-(4-chlorophenyl)-5-phenylthiazol-2-yl][1-(4-chlorophenyl)-1H-[1,2,3]triazol-4-yl]methylamine

[4-(4-chlorophenyl)-5-phenylthiazol-2-yl][1-(4-nitrophenyl)-1H-[1,2,3]triazol-4-yl]methylamine

[4-(4-chlorophenyl)-5-phenylthiazol-2-yl](1-o-tolyl-1H-[1,2,3]triazol-4-yl)methylamine

[4-(4-chlorophenyl)-5-phenylthiazol-2-yl][1-(2-chlorophenyl)-1H-[1,2,3]triazol-4-yl]methylamine