3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-4-fluoro-benzoic acid

Base Information

Chemical Name:3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-4-fluoro-benzoic acid
CAS No.:1306754-33-5
Molecular Formula:C₂₁H₁₅F₃O₄
Molecular Weight:388.343
Hs Code.:

Synonyms:3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-4-fluoro-benzoic acid

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Chemical Property of 3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-4-fluoro-benzoic acid

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Technology Process of 3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-4-fluoro-benzoic acid

There total 5 articles about 3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-4-fluoro-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1306754-35-7
3-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester

: 1306754-33-5
3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-4-fluoro-benzoic acid

Guidance literature:: 3-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester; With methanol; lithium hydroxide; for 2h; Reflux;

With hydrogenchloride; In water;

Reference yield:

: 403-15-6
4-fluoro-3-methyl-benzoic acid

: 1306754-33-5
3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-4-fluoro-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / water / 4 h / Reflux

2: dibenzoyl peroxide / tetrachloromethane / 6 h / Reflux

3: potassium carbonate / acetone / 6 h / Reflux

4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 45 °C

5: lithium hydroxide; methanol / 2 h / Reflux

With hydrogenchloride; methanol; potassium carbonate; lithium hydroxide; dibenzoyl peroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrachloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 878744-25-3
methyl 3-(bromomethyl)-4-fluorobenzoate

: 1306754-33-5
3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-4-fluoro-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 6 h / Reflux

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 45 °C

3: lithium hydroxide; methanol / 2 h / Reflux

With methanol; potassium carbonate; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; acetone;