1-{2-[3-acetylamino-5-(pentafluorosulfanyl)phenyl]-2-oxoethyl}-3-amino-6-ethoxy-[1,2,4]triazolo[4,3-b]pyridazin-1-ium trifluoroacetate

Base Information

Chemical Name:1-{2-[3-acetylamino-5-(pentafluorosulfanyl)phenyl]-2-oxoethyl}-3-amino-6-ethoxy-[1,2,4]triazolo[4,3-b]pyridazin-1-ium trifluoroacetate
CAS No.:1180517-32-1
Molecular Formula:C₂F₃O₂*C₁₇H₁₈F₅N₆O₃S
Molecular Weight:594.442
Hs Code.:

Synonyms:1-{2-[3-acetylamino-5-(pentafluorosulfanyl)phenyl]-2-oxoethyl}-3-amino-6-ethoxy-[1,2,4]triazolo[4,3-b]pyridazin-1-ium trifluoroacetate

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Chemical Property of 1-{2-[3-acetylamino-5-(pentafluorosulfanyl)phenyl]-2-oxoethyl}-3-amino-6-ethoxy-[1,2,4]triazolo[4,3-b]pyridazin-1-ium trifluoroacetate

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Technology Process of 1-{2-[3-acetylamino-5-(pentafluorosulfanyl)phenyl]-2-oxoethyl}-3-amino-6-ethoxy-[1,2,4]triazolo[4,3-b]pyridazin-1-ium trifluoroacetate

There total 10 articles about 1-{2-[3-acetylamino-5-(pentafluorosulfanyl)phenyl]-2-oxoethyl}-3-amino-6-ethoxy-[1,2,4]triazolo[4,3-b]pyridazin-1-ium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1178581-70-8
6-Ethoxy-[1,2,4]triazolo[4,3-b]-pyridazin-3-ylamine

: 1178584-06-9
N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]acetamide

: 76-05-1
trifluoroacetic acid

: 1180517-32-1
1-{2-[3-acetylamino-5-(pentafluorosulfanyl)phenyl]-2-oxoethyl}-3-amino-6-ethoxy-[1,2,4]triazolo[4,3-b]pyridazin-1-ium trifluoroacetate

Guidance literature:: 6-Ethoxy-[1,2,4]triazolo[4,3-b]-pyridazin-3-ylamine; N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]acetamide; In N,N-dimethyl-formamide; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 852469-45-5
3-nitro-5-(pentafluoro-λ⁶-sulfanyl)benzoic acid

: 1180517-32-1
1-{2-[3-acetylamino-5-(pentafluorosulfanyl)phenyl]-2-oxoethyl}-3-amino-6-ethoxy-[1,2,4]triazolo[4,3-b]pyridazin-1-ium trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / dichloromethane / 20 °C / Reflux

2.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 °C

3.1: hydrogen / Raney nickel / methanol / 5 h

4.1: triethylamine / dichloromethane / 3 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran; tent-butyl methyl ether / 0.5 h / 0 °C

5.2: 5 h / 0 - 20 °C

5.3: Cooling with ice

6.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 5 h / 20 - 40 °C

7.1: N,N-dimethyl-formamide / 20 °C

With thionyl chloride; N,N-diethyl-N-isopropylamine; hydrogen; phenyltrimethylammonium tribromide; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; dichloromethane; tent-butyl methyl ether; N,N-dimethyl-formamide;

Reference yield:

: 1178585-39-1
N-methoxy-N-methyl-5-nitro-3-pentafluorosulfanylbenzamide

: 1180517-32-1
1-{2-[3-acetylamino-5-(pentafluorosulfanyl)phenyl]-2-oxoethyl}-3-amino-6-ethoxy-[1,2,4]triazolo[4,3-b]pyridazin-1-ium trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / Raney nickel / methanol / 5 h

2.1: triethylamine / dichloromethane / 3 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran; tent-butyl methyl ether / 0.5 h / 0 °C

3.2: 5 h / 0 - 20 °C

3.3: Cooling with ice

4.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 5 h / 20 - 40 °C

5.1: N,N-dimethyl-formamide / 20 °C

With hydrogen; phenyltrimethylammonium tribromide; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; dichloromethane; tent-butyl methyl ether; N,N-dimethyl-formamide;