2-(1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-1H-pyrazol-5-yl)-5-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole

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Chemical Name:2-(1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-1H-pyrazol-5-yl)-5-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole
CAS No.:1353877-27-6
Molecular Formula:C₃₂H₂₉ClN₄O₃
Molecular Weight:553.06
Hs Code.:

Synonyms:2-(1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-1H-pyrazol-5-yl)-5-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole

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Chemical Property of 2-(1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-1H-pyrazol-5-yl)-5-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole

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Technology Process of 2-(1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-1H-pyrazol-5-yl)-5-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole

There total 5 articles about 2-(1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-1H-pyrazol-5-yl)-5-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1353877-21-0
C₃₂H₃₁ClN₄O₄

: 1353877-27-6
2-(1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-1H-pyrazol-5-yl)-5-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole

Guidance literature:: With trichlorophosphate; at 70 - 80 ℃;
DOI:10.1016/j.saa.2011.10.021

Reference yield:

: 75908-67-7
3-bromo-7-methoxy-4-methylcoumarin

: 1353877-27-6
2-(1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-1H-pyrazol-5-yl)-5-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol / Reflux

1.2: Reflux

2.1: triethylamine / dichloromethane / 20 °C

3.1: trichlorophosphate / 70 - 80 °C

With triethylamine; potassium hydroxide; trichlorophosphate; In ethanol; dichloromethane;
DOI:10.1016/j.saa.2011.10.021

Reference yield:

: ethyl 3-(4-chlorophenyl)-1-([4-(1,1-dimethylethyl)phenyl]methyl)-1H-pyrazole-5-carboxylate

: 1353877-27-6
2-(1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-1H-pyrazol-5-yl)-5-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / Reflux

2: triethylamine / dichloromethane / 20 °C

3: trichlorophosphate / 70 - 80 °C

With hydrazine hydrate; triethylamine; trichlorophosphate; In methanol; dichloromethane;
DOI:10.1016/j.saa.2011.10.021