5-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 4-ethyl ester

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 4-ethyl ester
CAS No.:952019-85-1
Molecular Formula:C₂₂H₂₀ClNO₅
Molecular Weight:413.858
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 4-ethyl ester

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Chemical Property of 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 4-ethyl ester

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Technology Process of 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 4-ethyl ester

There total 5 articles about 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 952019-77-1
2-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester

: 952019-85-1
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 4-ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1080/00397910701481237

Reference yield:

: 952019-72-6
2-acetyl-3-(4-chlorobenzoyl)succinic acid 4-tert-butyl ester 1-ethyl ester

: 952019-85-1
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 4-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / AcOH / 24 h / Heating

2: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

With acetic acid; trifluoroacetic acid; In dichloromethane; 1: Paal-Knorr cyclization;
DOI:10.1080/00397910701481237

Reference yield:

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

: 952019-85-1
5-(4-chlorophenyl)-1-(4-methoxyphenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 4-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

1.2: 100 percent / tetrahydrofuran / 4 h / -78 - 20 °C

2.1: EtONa / ethanol / 0.17 h

2.2: 19 percent / ethanol; toluene / 7 h / 20 °C

3.1: 48 percent / AcOH / 24 h / Heating

4.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

With sodium ethanolate; acetic acid; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; 3.1: Paal-Knorr cyclization;
DOI:10.1080/00397910701481237