2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-3H-imidazole-4-carboxylic acid trifluoracetate salt

Base Information

Chemical Name:2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-3H-imidazole-4-carboxylic acid trifluoracetate salt
CAS No.:1354692-82-2
Molecular Formula:C₂HF₃O₂*C₂₈H₂₇Cl₂F₂N₅O₃
Molecular Weight:704.481
Hs Code.:

2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-3H-imidazole-4-carboxylic acid trifluoracetate salt

Synonyms:2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-3H-imidazole-4-carboxylic acid trifluoracetate salt

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Chemical Property of 2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-3H-imidazole-4-carboxylic acid trifluoracetate salt

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Technology Process of 2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-3H-imidazole-4-carboxylic acid trifluoracetate salt

There total 4 articles about 2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-3H-imidazole-4-carboxylic acid trifluoracetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354693-53-0
2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]amino}-3H-imidazole-4-carboxylic acid ethyl ester

: 1354692-82-2
2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-3H-imidazole-4-carboxylic acid trifluoracetate salt

Guidance literature:: With potassium hydroxide; In ethanol; dimethyl sulfoxide; at 20 ℃; for 15h;

Reference yield:

: 1354693-60-9
rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid methyl ester

: 1354692-82-2
2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-3H-imidazole-4-carboxylic acid trifluoracetate salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / 0 - 20 °C

2.1: lithium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 25 °C

3.2: 20 °C

4.1: potassium hydroxide / ethanol; dimethyl sulfoxide / 15 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; 1,1'-carbonyldiimidazole; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1354693-55-2
(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid

: 1354692-82-2
2-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carbonyl]-amino}-3H-imidazole-4-carboxylic acid trifluoracetate salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 25 °C

1.2: 20 °C

2.1: potassium hydroxide / ethanol; dimethyl sulfoxide / 15 h / 20 °C

With 1,1'-carbonyldiimidazole; potassium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide;