2'-chloro-4'-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3'-methylbenzonitrile

Base Information

Chemical Name:2'-chloro-4'-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3'-methylbenzonitrile
CAS No.:1114546-02-9
Molecular Formula:C₁₄H₁₅ClN₂O₂
Molecular Weight:278.738
Hs Code.:

Synonyms:2'-chloro-4'-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3'-methylbenzonitrile

Suppliers and Price of 2'-chloro-4'-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3'-methylbenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2'-chloro-4'-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3'-methylbenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2'-chloro-4'-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3'-methylbenzonitrile

There total 6 articles about 2'-chloro-4'-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3'-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1114547-25-9
4-[(2S,3S)-3-(tert-butyldimethylsilyloxy)-2-ethyl-5-oxopyrrolidin-1-yl]-2-chloro-3-methylbenzonitrile

: 1114546-02-9
2'-chloro-4'-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3'-methylbenzonitrile

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; for 18h;

Reference yield: 6.0%

: 1114547-15-7
(2S,3S)-3-(tert-butyldimethylsilyloxy)-2-ethylpyrrolidin-5-one

: 1114546-02-9
2'-chloro-4'-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3'-methylbenzonitrile

Guidance literature:: (2S,3S)-3-(tert-butyldimethylsilyloxy)-2-ethylpyrrolidin-5-one; 4-halo-2-chloro-3-methylbenzonitrile; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; for 12h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2017.04.018

Reference yield:

: 1114547-11-3
ethyl (4S)-4-[(benzyloxy)carbonyl]amino-3-hydroxyhexanoate

: 1114546-02-9
2'-chloro-4'-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-3'-methylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / 0 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 3.5 h / 20 °C

2.2: 1 h / 20 °C

3.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; 3.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2017.04.018