triglycolic acid di-(2-p-tolylamino)anilide

Base Information

• Chemical Name: triglycolic acid di-(2-p-tolylamino)anilide
• CAS No.: 91540-08-8
• Molecular Formula: C₃₂H₃₄N₄O₈S₂
• Molecular Weight: 666.776
• Mol file: 91540-08-8.mol

Synonyms:triglycolic acid di-(2-p-tolylamino)anilide

Chemical Property of triglycolic acid di-(2-p-tolylamino)anilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of triglycolic acid di-(2-p-tolylamino)anilide

There total 1 articles about triglycolic acid di-(2-p-tolylamino)anilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3,6-dioxa-1,8-octanoyl dichloride (31255-09-1) + N-tosyl-1,2-diaminobenzene (3624-90-6) → triglycolic acid di-(2-p-tolylamino)anilide (91540-08-8)

Guidance literature:

In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4020(01)91109-3

Reference yield: 84.0%

triglycolic acid di-(2-p-tolylamino)anilide (91540-08-8) → 1,2-di<2-<2-(p-tolylamino)anilino>ethoxy>ethane (91755-59-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;

DOI:10.1016/S0040-4020(01)91109-3

Reference yield:

triglycolic acid di-(2-p-tolylamino)anilide (91540-08-8) → 7,16-di<2-(3-carboxypropionylamino)>phenyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane (91540-14-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 84 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

2: 62 percent / pyridine / benzene / 16 h / Heating

3: 61 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

4: 70 percent / sodium-naphthalene / tetrahydrofuran / 1.5 h / -10 °C

5: 50 percent / pyridine / 24 h

With pyridine; lithium aluminium tetrahydride; naphthalene; sodium; In tetrahydrofuran; pyridine; benzene;

DOI:10.1016/S0040-4020(01)91109-3

upstream raw materials:

3,6-dioxa-1,8-octanoyl dichloride

N-tosyl-1,2-diaminobenzene

Downstream raw materials:

1,2-di<2-<2-(p-tolylamino)anilino>ethoxy>ethane

7,16-di<2-(3-carboxypropionylamino)>phenyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

7,16-di<2-(p-tolylamino)phenyl>-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

9,18-di<2-(p-tolylamino)phenyl>-1,8-dioxo-3,6,12,15-tetraoxa-9,18-diazacycloocta-decane