2-(7-{[N-({4-[({(1R)-3-phenyl-1-[N-(phenylmethoxy)carbamoyl]propyl}amino)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

Base Information

Chemical Name:2-(7-{[N-({4-[({(1R)-3-phenyl-1-[N-(phenylmethoxy)carbamoyl]propyl}amino)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt
CAS No.:1173156-44-9
Molecular Formula:C₂HF₃O₂*C₄₁H₅₅N₇O₉
Molecular Weight:903.953
Hs Code.:

2-(7-{[N-({4-[({(1R)-3-phenyl-1-[N-(phenylmethoxy)carbamoyl]propyl}amino)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

Synonyms:2-(7-{[N-({4-[({(1R)-3-phenyl-1-[N-(phenylmethoxy)carbamoyl]propyl}amino)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

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Chemical Property of 2-(7-{[N-({4-[({(1R)-3-phenyl-1-[N-(phenylmethoxy)carbamoyl]propyl}amino)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

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Technology Process of 2-(7-{[N-({4-[({(1R)-3-phenyl-1-[N-(phenylmethoxy)carbamoyl]propyl}amino)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

There total 16 articles about 2-(7-{[N-({4-[({(1R)-3-phenyl-1-[N-(phenylmethoxy)carbamoyl]propyl}amino)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173158-89-8
C₅₃H₇₉N₇O₉

: 76-05-1
trifluoroacetic acid

: 1173156-44-9
2-(7-{[N-({4-[({(1R)-3-phenyl-1-[N-(phenylmethoxy)carbamoyl]propyl}amino)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

Guidance literature:: C₅₃H₇₉N₇O₉; With hydrogenchloride; In 1,4-dioxane; water; at 22 ℃; for 17h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 1173156-44-9
2-(7-{[N-({4-[({(1R)-3-phenyl-1-[N-(phenylmethoxy)carbamoyl]propyl}amino)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.25 h

3.1: Dess-Martin periodane / dichloromethane / 0.08 h / 22 °C / Reflux

4.1: sodium cyanoborohydride / methanol / 1 h / 0 °C

4.2: 4 h

5.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 22 °C

6.1: diethylamine / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 0.25 h / 22 °C

7.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 22 °C

8.1: hydrogenchloride / 1,4-dioxane; water / 17 h / 22 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium cyanoborohydride; benzotriazol-1-ol; Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1007859-08-6
N-((4-(hydroxymethyl)phenyl)methyl)prop-2-enyloxycarboxamide

: 1173156-44-9
2-(7-{[N-({4-[({(1R)-3-phenyl-1-[N-(phenylmethoxy)carbamoyl]propyl}amino)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: Dess-Martin periodane / dichloromethane / 0.08 h / 22 °C / Reflux

2.1: sodium cyanoborohydride / methanol / 1 h / 0 °C

2.2: 4 h

3.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 22 °C

4.1: diethylamine / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 0.25 h / 22 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 22 °C

6.1: hydrogenchloride / 1,4-dioxane; water / 17 h / 22 °C

With hydrogenchloride; sodium cyanoborohydride; benzotriazol-1-ol; Dess-Martin periodane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;