2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide

Base Information

Chemical Name:2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide
CAS No.:1380049-42-2
Molecular Formula:C₁₈H₂₂N₂O₃S
Molecular Weight:346.45
Hs Code.:

Synonyms:2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide

Suppliers and Price of 2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of 2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide

Chemical Property:

Purity/Quality:: NLT 98% ^*data from raw suppliers

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Technology Process of 2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide

There total 2 articles about 2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

: 78-77-3
Isobutyl bromide

: 1380049-41-1
2-(3-formyl-4-hydroxyphenyl)-N,N,4-trimethylthiazole-5-carboxamide

: 1380049-42-2
2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; at 25 - 65 ℃; Product distribution / selectivity;

Reference yield:

: 1380049-39-7
2-(4-hydroxyphenyl)-N,N-4-trimethylthiazole-5-carboxamide

: 1380049-42-2
2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: polyphosphoric acid / 0.5 h / 70 - 72 °C

1.2: 72 - 78 °C

2.1: potassium carbonate; potassium iodide; tetrabutylammomium bromide / N,N-dimethyl-formamide; tetrahydrofuran / 25 - 65 °C

With tetrabutylammomium bromide; potassium carbonate; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 1.2: Duff Reaction;

Reference yield: 92.7%

: 1380049-42-2
2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide

: 144060-62-8
2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid

Guidance literature:: 2-[3-formyl-4-(2-methylpropoxy)phenyl]-N,N-4-trimethylthiazole-5-carboxamide; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 25 - 60 ℃;

With hydrogenchloride; In water; at 20 - 30 ℃; pH=2;