(2R)-2-[4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododec-1-yl]pentanedioic acid 1-tert-butyl ester 5-pentafluorophenyl ester

Base Information

• Chemical Name: (2R)-2-[4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododec-1-yl]pentanedioic acid 1-tert-butyl ester 5-pentafluorophenyl ester
• CAS No.: 817562-91-7
• Molecular Formula: C₄₁H₆₃F₅N₄O₁₀
• Molecular Weight: 866.964
• Mol file: 817562-91-7.mol

Synonyms:(2R)-2-[4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododec-1-yl]pentanedioic acid 1-tert-butyl ester 5-pentafluorophenyl ester

Chemical Property of (2R)-2-[4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododec-1-yl]pentanedioic acid 1-tert-butyl ester 5-pentafluorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-[4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododec-1-yl]pentanedioic acid 1-tert-butyl ester 5-pentafluorophenyl ester

There total 1 articles about (2R)-2-[4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododec-1-yl]pentanedioic acid 1-tert-butyl ester 5-pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl ester (817562-90-6) + 2,3,4,5,6-pentafluorophenol (771-61-9) → (2R)-2-[4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododec-1-yl]pentanedioic acid 1-tert-butyl ester 5-pentafluorophenyl ester (817562-91-7)

Guidance literature:

With polystyrene carbodiimide; In dichloromethane; at 22 - 25 ℃; for 2 - 6h; Product distribution / selectivity;

Reference yield:

(2R)-2-[4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododec-1-yl]pentanedioic acid 1-tert-butyl ester 5-pentafluorophenyl ester (817562-91-7) + (R)-1-phenyl-ethyl-amine (3886-69-9) → tri-tert-butyl 2,2′,2″-(10-((R)-1-(tert-butoxy)-1,5-dioxo-5-(((R)-1-phenylethyl)amino)pentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (817562-92-8)

Guidance literature:

In tetrahydrofuran; for 0.5h; Product distribution / selectivity;

upstream raw materials:

2-(R)-2-(4,7,10-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododec-1-yl)-pentanedioic acid, 1-tert-butyl ester

2,3,4,5,6-pentafluorophenol

Downstream raw materials:

tri-tert-butyl 2,2′,2″-(10-((R)-1-(tert-butoxy)-1,5-dioxo-5-(((R)-1-phenylethyl)amino)pentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate