2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoyl-phenylalanine amide

Base Information

Chemical Name:2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoyl-phenylalanine amide
CAS No.:246538-47-6
Molecular Formula:C₂₃H₂₄F₃N₃O₄
Molecular Weight:463.456
Hs Code.:

Synonyms:2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoyl-phenylalanine amide

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Chemical Property of 2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoyl-phenylalanine amide

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Technology Process of 2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoyl-phenylalanine amide

There total 2 articles about 2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoyl-phenylalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.9%

: 65864-22-4
(S)-2-amino-3-phenylpropionamide hydrochloride

: 246538-46-5
2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoic acid

: 246538-47-6
2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoyl-phenylalanine amide

Guidance literature:: 2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoic acid; With dicyclohexyl-carbodiimide; at 0 - 20 ℃;

(S)-2-amino-3-phenylpropionamide hydrochloride; With TEA; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoic acid ethyl ester

: 246538-47-6
2-(N-benzyloxycarbonylamino)-2-trifluoromethyl-4-pentenoyl-phenylalanine amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97.2 percent / aq. KOH / methanol / 20 °C

2.1: N,N-dicyclohexylcarbodiimide / 0 - 20 °C

2.2: 89.9 percent / TEA / dimethylformamide / 20 °C

With potassium hydroxide; dicyclohexyl-carbodiimide; In methanol; 1.1: Hydrolysis / 2.1: Cycloaddition / 2.2: Ring cleavage;