N-phenyl,N-tert-butyloxycarbonyl 4-(tetrahydro-2H-pyran-2-yl)-but-2-ynamide

Base Information

Chemical Name:N-phenyl,N-tert-butyloxycarbonyl 4-(tetrahydro-2H-pyran-2-yl)-but-2-ynamide
CAS No.:310883-78-4
Molecular Formula:C₂₀H₂₅NO₄
Molecular Weight:343.423
Hs Code.:

Synonyms:N-phenyl,N-tert-butyloxycarbonyl 4-(tetrahydro-2H-pyran-2-yl)-but-2-ynamide

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Chemical Property of N-phenyl,N-tert-butyloxycarbonyl 4-(tetrahydro-2H-pyran-2-yl)-but-2-ynamide

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Technology Process of N-phenyl,N-tert-butyloxycarbonyl 4-(tetrahydro-2H-pyran-2-yl)-but-2-ynamide

There total 3 articles about N-phenyl,N-tert-butyloxycarbonyl 4-(tetrahydro-2H-pyran-2-yl)-but-2-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 310883-77-3
N-phenyl 4-(tetrahydro-2H-pyran-2-yl)but-2-ynamide

: 310883-78-4
N-phenyl,N-tert-butyloxycarbonyl 4-(tetrahydro-2H-pyran-2-yl)-but-2-ynamide

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1021/ja002356g

Reference yield:

: 100-72-1
Tetrahydropyran-2-methanol

: 310883-78-4
N-phenyl,N-tert-butyloxycarbonyl 4-(tetrahydro-2H-pyran-2-yl)-but-2-ynamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / CH₂Cl₂ / 0.33 h / -5 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

2.2: 90 percent / tetrahydrofuran; hexane / 5 h / -10 °C

3.1: 99 percent / 4-(dimethylamino)pyridine / acetonitrile / 0.5 h / 20 °C

With pyridine; dmap; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1021/ja002356g

Reference yield:

: 123136-03-8
(tetrahydro-2H-pyran-2-yl)methyl trifluoromethanesulfonate

: 310883-78-4
N-phenyl,N-tert-butyloxycarbonyl 4-(tetrahydro-2H-pyran-2-yl)-but-2-ynamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C

1.2: 90 percent / tetrahydrofuran; hexane / 5 h / -10 °C

2.1: 99 percent / 4-(dimethylamino)pyridine / acetonitrile / 0.5 h / 20 °C

With dmap; n-butyllithium; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/ja002356g