3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-5-(pyridin-2-yl)-4,5-dihydro-1,2,4-oxadiazole

Base Information

Chemical Name:3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-5-(pyridin-2-yl)-4,5-dihydro-1,2,4-oxadiazole
CAS No.:1353884-49-7
Molecular Formula:C₂₇H₂₄ClN₅O₂
Molecular Weight:485.973
Hs Code.:

Synonyms:3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-5-(pyridin-2-yl)-4,5-dihydro-1,2,4-oxadiazole

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Chemical Property of 3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-5-(pyridin-2-yl)-4,5-dihydro-1,2,4-oxadiazole

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Technology Process of 3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-5-(pyridin-2-yl)-4,5-dihydro-1,2,4-oxadiazole

There total 3 articles about 3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-5-(pyridin-2-yl)-4,5-dihydro-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34035-03-5
5-(4-chlorophenyl)-2-furaldehyde

: 1353884-49-7
3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-5-(pyridin-2-yl)-4,5-dihydro-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; hydroxylamine hydrochloride / 20 °C / Inert atmosphere

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml200238g

Reference yield:

: C₃₂H₃₂ClN₅O₄

: 1353884-49-7
3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-5-(pyridin-2-yl)-4,5-dihydro-1,2,4-oxadiazole

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h; Inert atmosphere;
DOI:10.1021/ml200238g

Reference yield:

: 52507-66-1,57128-15-1,39170-10-0
5-(4'-chlorophenyl)furan-2-carbaldehyde oxime

: 1353884-49-7
3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-5-(pyridin-2-yl)-4,5-dihydro-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

With N-chloro-succinimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml200238g