(1S,2S,3R)-methyl 2-(4-(trifluoromethyl)phenyl)bicyclo[1.1.0]butane-1-carboxylate

Base Information

Chemical Name:(1S,2S,3R)-methyl 2-(4-(trifluoromethyl)phenyl)bicyclo[1.1.0]butane-1-carboxylate
CAS No.:1417719-52-8
Molecular Formula:C₁₃H₁₁F₃O₂
Molecular Weight:256.224
Hs Code.:

Synonyms:(1S,2S,3R)-methyl 2-(4-(trifluoromethyl)phenyl)bicyclo[1.1.0]butane-1-carboxylate

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Chemical Property of (1S,2S,3R)-methyl 2-(4-(trifluoromethyl)phenyl)bicyclo[1.1.0]butane-1-carboxylate

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Technology Process of (1S,2S,3R)-methyl 2-(4-(trifluoromethyl)phenyl)bicyclo[1.1.0]butane-1-carboxylate

There total 3 articles about (1S,2S,3R)-methyl 2-(4-(trifluoromethyl)phenyl)bicyclo[1.1.0]butane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1417719-43-7
(E)-methyl 2-diazo-5-(4-(trifluoromethyl)phenyl)pent-4-enoate

: 1417719-52-8
(1S,2S,3R)-methyl 2-(4-(trifluoromethyl)phenyl)bicyclo[1.1.0]butane-1-carboxylate

Guidance literature:: With Rh₂(S-BTPCP)4; In ethyl acetate; at 20 ℃; for 0.75h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol303217s

Reference yield:

: 1417719-36-8
C₁₅H₁₅F₃O₃

: 1417719-52-8
(1S,2S,3R)-methyl 2-(4-(trifluoromethyl)phenyl)bicyclo[1.1.0]butane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 3 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: Rh₂(S-BTPCP)4 / ethyl acetate / 0.75 h / 20 °C / Inert atmosphere

With 4-acetamidobenzenesulfonyl azide; Rh₂(S-BTPCP)4; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; ethyl acetate;
DOI:10.1021/ol303217s

Reference yield:

: 762247-01-8
(E)-1-(3-bromoprop-1-en-1-yl)-4-(trifluoromethyl)benzene

: 1417719-52-8
(1S,2S,3R)-methyl 2-(4-(trifluoromethyl)phenyl)bicyclo[1.1.0]butane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride; tetra-(n-butyl)ammonium iodide / 1,2-dimethoxyethane / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 85 °C / Inert atmosphere

2.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C

3.1: Rh₂(S-BTPCP)4 / ethyl acetate / 0.75 h / 20 °C / Inert atmosphere

With 4-acetamidobenzenesulfonyl azide; Rh₂(S-BTPCP)4; tetra-(n-butyl)ammonium iodide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,2-dimethoxyethane; dichloromethane; ethyl acetate;
DOI:10.1021/ol303217s