ethyl 2-((2R,3S,5S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-2-hydroxypropanoate

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Chemical Name:ethyl 2-((2R,3S,5S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-2-hydroxypropanoate
CAS No.:1219930-50-3
Molecular Formula:C₃₀H₃₇FN₂O₇Si
Molecular Weight:584.717
Hs Code.:

ethyl 2-((2R,3S,5S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-2-hydroxypropanoate

Synonyms:ethyl 2-((2R,3S,5S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-2-hydroxypropanoate

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Chemical Property of ethyl 2-((2R,3S,5S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-2-hydroxypropanoate

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Technology Process of ethyl 2-((2R,3S,5S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-2-hydroxypropanoate

There total 1 articles about ethyl 2-((2R,3S,5S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 617-35-6
2-oxo-propionic acid ethyl ester

: 149204-36-4
(1S)-1-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dihydrofuran

: 17242-85-2
5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine

: 1219930-50-3
ethyl 2-((2R,3S,5S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-2-hydroxypropanoate

Guidance literature:: 2-oxo-propionic acid ethyl ester; (1S)-1-<<(tert-butyldiphenylsilyl)oxy>methyl>-2,3-dihydrofuran; With titanium tetrachloride; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine; In dichloromethane; at -78 - 23 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1039/b924807b