2-((2-((3-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Base Information

Chemical Name:2-((2-((3-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1564256-35-4
Molecular Formula:C₂₅H₂₇ClN₆O₂
Molecular Weight:478.981
Hs Code.:

Synonyms:2-((2-((3-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((2-((3-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((2-((3-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

There total 7 articles about 2-((2-((3-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.3%

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 1564256-80-9
C₁₃H₁₈N₂O

: 1564256-35-4
2-((2-((3-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With (1S)-10-camphorsulfonic acid; In isopropyl alcohol; at 80 ℃; for 1h; Microwave irradiation;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-60-5
C₁₈H₁₈N₂O₂

: 1564256-35-4
2-((2-((3-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / 1,2-dichloro-ethane / 2 h / Reflux

2: methanol / Reflux

3: triethylamine / dichloromethane / 2 h / 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 4 h

5: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With palladium 10% on activated carbon; (1S)-10-camphorsulfonic acid; hydrogen; potassium carbonate; triethylamine; In methanol; dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1021/ml400373j

Reference yield:

: 1564256-63-8
C₁₁H₁₂N₂O₂

: 1564256-35-4
2-((2-((3-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h

3: (1S)-10-camphorsulfonic acid / isopropyl alcohol / 1 h / 80 °C / Microwave irradiation

With palladium 10% on activated carbon; (1S)-10-camphorsulfonic acid; hydrogen; triethylamine; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/ml400373j