(1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride

Base Information

• Chemical Name: (1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride
• CAS No.: 88784-91-2
• Molecular Formula: C₉H₁₃NO*ClH
• Molecular Weight: 187.669
• Mol file: 88784-91-2.mol

Synonyms:(1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride

Chemical Property of (1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(1R,2S)-1-Amino-1-phenylpropan-2-olhydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride

There total 6 articles about (1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(-)-(1R,2S)-1-azido-1-phenyl-2-propanol (255060-78-7) → (1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride (88784-91-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 16h; under 2585.74 Torr;

DOI:10.1021/jm9910021

Reference yield: 66.0%

(S)-1-Phenyl-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-propylamine (133735-63-4,133812-92-7,133812-94-9,133812-95-0,135028-72-7,135028-73-8) → (1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride (88784-91-2)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Ambient temperature;

DOI:10.1007/BF00810829

Reference yield:

(1S,2S)-(-)-1-phenyl-1-propene oxide (4518-66-5) → (1R,2S)-1-amino-1-phenylpropan-2-ol hydrochloride (88784-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / NaN₃; NH₄Cl / ethanol; H₂O / 2 h / Heating

2: 79 percent / H₂; aq. HCl / 10 percent Pd/C / ethanol / 16 h / 2585.74 Torr

With hydrogenchloride; sodium azide; hydrogen; ammonium chloride; palladium on activated charcoal; In ethanol; water; 1: Ring cleavage / 2: Reduction;

DOI:10.1021/jm9910021

upstream raw materials:

(S)-1-Phenyl-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-propylamine

(-)-(1R,2S)-1-azido-1-phenyl-2-propanol

(R_S,2S)-2-methyl-propane-2-sulfinic acid (2-benzyloxy-1-phenyl-propyl)-amide

(1S,2S)-(-)-1-phenyl-1-propene oxide

Downstream raw materials:

(1R,2S)-1-[N-(tert-butoxycarbonyl)amino]-1-phenylpropan-2-ol

N-[(1R,2S)-2-hydroxy-1-phenylpropyl]octanamide

(4R,5S)-5-methyl-4-phenyloxazolidin-2-one

(1R,2R)-1--1-phenylpropan-2-ol