ethyl (3S)-[4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]pent-4-ynate

Base Information

Chemical Name:ethyl (3S)-[4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]pent-4-ynate
CAS No.:882531-28-4
Molecular Formula:C₂₂H₂₅N₅O₃
Molecular Weight:407.472
Hs Code.:

Synonyms:ethyl (3S)-[4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]pent-4-ynate

Suppliers and Price of ethyl (3S)-[4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]pent-4-ynate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (3S)-[4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]pent-4-ynate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (3S)-[4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]pent-4-ynate

There total 4 articles about ethyl (3S)-[4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]pent-4-ynate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 234081-73-3
4-{4-(Pyrimidin-2-yl)-piperazin-1-yl}-benzoic acid

: 149251-15-0
ethyl 3-amino-(3S)-ethynylpropionate hydrochloride

: 882531-28-4
ethyl (3S)-[4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]pent-4-ynate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 23h;
DOI:10.1016/j.bmc.2005.10.060

Reference yield:

: 233283-14-2
ethyl 4-{4-(pyrimidin-2-yl)-piperazin-1-yl}-benzoate

: 882531-28-4
ethyl (3S)-[4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]pent-4-ynate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaOH / methanol; tetrahydrofuran; H₂O / 5 h / 40 °C

2: 55 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 23 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.060

Reference yield:

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 882531-28-4
ethyl (3S)-[4-{4-(pyrimidin-2-yl)piperazin-1-yl}benzoylamino]pent-4-ynate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / dimethylsulfoxide / 20 h / 120 °C

2: 95 percent / N,N-diisopropylethylamine / dimethylformamide / 4.5 h / 120 °C

3: 100 percent / NaOH / methanol; tetrahydrofuran; H₂O / 5 h / 40 °C

4: 55 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 23 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.060