[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(1-benzyloxymethylvinyl)phenyl]methanone

Base Information

Chemical Name:[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(1-benzyloxymethylvinyl)phenyl]methanone
CAS No.:882175-35-1
Molecular Formula:C₂₆H₂₂FN₃O₂
Molecular Weight:427.478
Hs Code.:

Synonyms:[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(1-benzyloxymethylvinyl)phenyl]methanone

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Chemical Property of [5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(1-benzyloxymethylvinyl)phenyl]methanone

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Technology Process of [5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(1-benzyloxymethylvinyl)phenyl]methanone

There total 5 articles about [5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(1-benzyloxymethylvinyl)phenyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 249937-23-3
5-amino-1-(4-fluorophenyl)-4-(3-iodobenzoyl)pyrazole

: 79629-41-7
(((2-bromoallyl)oxy)methyl)benzene

: 882175-35-1
[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(1-benzyloxymethylvinyl)phenyl]methanone

Guidance literature:: 5-amino-1-(4-fluorophenyl)-4-(3-iodobenzoyl)pyrazole; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; bis(pinacol)diborane; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

(((2-bromoallyl)oxy)methyl)benzene; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 80 ℃; for 18h;
DOI:10.1021/jm050736c

Reference yield:

: 2-(3-iodobenzoyl)-3-phenylaminoacrylonitrile

: 882175-35-1
[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(1-benzyloxymethylvinyl)phenyl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75.1 g / ethanol / 0.5 h / Heating

2.1: K₂CO₃; diboron pinacol ester; [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂*CH₂Cl₂ / dimethylformamide / 2 h / 80 °C

2.2: 380 mg / [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂*CH₂Cl₂; aq. NaHCO₃ / dimethylformamide / 18 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; bis(pinacol)diborane; In ethanol; N,N-dimethyl-formamide; 2.2: Suzuki coupling;
DOI:10.1021/jm050736c

Reference yield:

: 58313-23-8
3-iodobenzoic acid methyl ester

: 882175-35-1
[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(1-benzyloxymethylvinyl)phenyl]methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran; hexane

1.2: 8.3 g / tetrahydrofuran; hexane / 3 h / -50 °C

2.1: 31.2 g / toluene / 8 h / Heating

3.1: 75.1 g / ethanol / 0.5 h / Heating

4.1: K₂CO₃; diboron pinacol ester; [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂*CH₂Cl₂ / dimethylformamide / 2 h / 80 °C

4.2: 380 mg / [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂*CH₂Cl₂; aq. NaHCO₃ / dimethylformamide / 18 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; bis(pinacol)diborane; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; toluene; 4.2: Suzuki coupling;
DOI:10.1021/jm050736c