(+/-)-α-(acetylamino)-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

Base Information

Chemical Name:(+/-)-α-(acetylamino)-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid
CAS No.:127152-94-7
Molecular Formula:C₁₇H₂₃NO₅
Molecular Weight:321.373
Hs Code.:

Synonyms:(+/-)-α-(acetylamino)-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

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Chemical Property of (+/-)-α-(acetylamino)-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

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Technology Process of (+/-)-α-(acetylamino)-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

There total 5 articles about (+/-)-α-(acetylamino)-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 127152-88-9
(+/-)-α-(acetylamino)-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid phenylmethyl ester

: 127152-94-7
(+/-)-α-(acetylamino)-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;
DOI:10.1021/jm00107a037

Reference yield:

: 33155-60-1
t-butyl p-tolylacetate

: 127152-94-7
(+/-)-α-(acetylamino)-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 32 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / Heating

2: 50 percent / 10percent aq. NaOH / tetrabutyl ammonium sulfate / CH₂Cl₂ / 5 h / Ambient temperature

3: 87 percent / acetonitrile; H₂O / 2 h / Ambient temperature

4: 80 percent / Et₃N / CH₂Cl₂ / 2 h

5: 91 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

With sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; hydrogen; triethylamine; palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate; In tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00107a037

Reference yield:

: 77292-91-2
α-(4-bromomethylphenyl)acetic acid tert-butyl ester

: 127152-94-7
(+/-)-α-(acetylamino)-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / 10percent aq. NaOH / tetrabutyl ammonium sulfate / CH₂Cl₂ / 5 h / Ambient temperature

2: 87 percent / acetonitrile; H₂O / 2 h / Ambient temperature

3: 80 percent / Et₃N / CH₂Cl₂ / 2 h

4: 91 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

With sodium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00107a037