<1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinic acid

Base Information

Chemical Name:<1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinic acid
CAS No.:115047-85-3
Molecular Formula:C₁₅H₂₂NO₆P
Molecular Weight:343.317
Hs Code.:

Synonyms:<1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinic acid

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Chemical Property of <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinic acid

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Technology Process of <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinic acid

There total 3 articles about <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115047-84-2
<1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinic acid

: 115047-85-3
<1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinic acid

Guidance literature:: With hydrogen; (-)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphanyl)butane; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In methanol; benzene; for 3h; under 2068.6 Torr;
DOI:10.1021/jm00117a017

Reference yield:

: 115047-83-1
methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinate

: 115047-85-3
<1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / anhydrous lithium iodide / tetrahydrofuran / 72 h / Ambient temperature

2: hydrogen, (-)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane / 1,5-cyclooctadienerhodium(I) chloride dimer / methanol; benzene / 3 h / 2068.6 Torr

With hydrogen; (-)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphanyl)butane; lithium iodide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In tetrahydrofuran; methanol; benzene;
DOI:10.1021/jm00117a017

Reference yield:

: 113592-51-1
methyl <1-(S)-<(benzyloxycarbonyl)amino>ethyl>phosphinate

: 115047-85-3
<1(S)-<(benzyloxycarbonyl)amino>ethyl>(2(R)-carbomethoxy-2-propyl)phosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

2: 82 percent / anhydrous lithium iodide / tetrahydrofuran / 72 h / Ambient temperature

3: hydrogen, (-)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane / 1,5-cyclooctadienerhodium(I) chloride dimer / methanol; benzene / 3 h / 2068.6 Torr

With hydrogen; (-)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphanyl)butane; lithium iodide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In tetrahydrofuran; methanol; benzene;
DOI:10.1021/jm00117a017