3-(4-chlorophenyl)-5-(2,2-difluoro-2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl)oxazolidin-2-one

Base Information

Chemical Name:3-(4-chlorophenyl)-5-(2,2-difluoro-2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl)oxazolidin-2-one
CAS No.:1428098-94-5
Molecular Formula:C₁₉H₁₄ClF₂N₃O₃
Molecular Weight:405.788
Hs Code.:

Synonyms:3-(4-chlorophenyl)-5-(2,2-difluoro-2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl)oxazolidin-2-one

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Chemical Property of 3-(4-chlorophenyl)-5-(2,2-difluoro-2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl)oxazolidin-2-one

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Technology Process of 3-(4-chlorophenyl)-5-(2,2-difluoro-2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl)oxazolidin-2-one

There total 3 articles about 3-(4-chlorophenyl)-5-(2,2-difluoro-2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.3%

: 947758-38-5
5-(difluoroiodomethyl)-3-phenyl-1,2,4-oxadiazole

: 1428098-35-4
benzyl allyl(4-chlorophenyl)carbamate

: 1428098-94-5
3-(4-chlorophenyl)-5-(2,2-difluoro-2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl)oxazolidin-2-one

Guidance literature:: With 2,2'-azobis(isobutyronitrile); In N,N-dimethyl-formamide; for 2.5h; Microwave irradiation;
DOI:10.1016/j.tet.2013.01.052

Reference yield:

: 6622-16-8
benzyl (4-chlorophenyl)carbamate

: 1428098-94-5
3-(4-chlorophenyl)-5-(2,2-difluoro-2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: 2,2'-azobis(isobutyronitrile) / N,N-dimethyl-formamide / 2.5 h / Microwave irradiation

With 2,2'-azobis(isobutyronitrile); sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.01.052

Reference yield:

: 106-47-8
4-chloro-aniline

: 1428098-94-5
3-(4-chlorophenyl)-5-(2,2-difluoro-2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: 2,2'-azobis(isobutyronitrile) / N,N-dimethyl-formamide / 2.5 h / Microwave irradiation

With 2,2'-azobis(isobutyronitrile); sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.01.052