(1S,2S)-2-[4-(methylcarbamoyl)benzyl]-2,3-dihydro-1H,1'H-2,2'-biinden-1-yl L-leucinate

Base Information

Chemical Name:(1S,2S)-2-[4-(methylcarbamoyl)benzyl]-2,3-dihydro-1H,1'H-2,2'-biinden-1-yl L-leucinate
CAS No.:1421333-25-6
Molecular Formula:C₃₃H₃₆N₂O₃
Molecular Weight:508.66
Hs Code.:

Synonyms:(1S,2S)-2-[4-(methylcarbamoyl)benzyl]-2,3-dihydro-1H,1'H-2,2'-biinden-1-yl L-leucinate

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Chemical Property of (1S,2S)-2-[4-(methylcarbamoyl)benzyl]-2,3-dihydro-1H,1'H-2,2'-biinden-1-yl L-leucinate

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Technology Process of (1S,2S)-2-[4-(methylcarbamoyl)benzyl]-2,3-dihydro-1H,1'H-2,2'-biinden-1-yl L-leucinate

There total 3 articles about (1S,2S)-2-[4-(methylcarbamoyl)benzyl]-2,3-dihydro-1H,1'H-2,2'-biinden-1-yl L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₈H₄₆N₂O₅

: 1421333-25-6
(1S,2S)-2-[4-(methylcarbamoyl)benzyl]-2,3-dihydro-1H,1'H-2,2'-biinden-1-yl L-leucinate

Guidance literature:: With dimethyl amine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

: 1380445-03-3
4-(((1S,2S)-2,3-dihydro-1-hydroxy-2-(1H-inden-2-yl)-1H-inden-2-yl)methyl)benzoic acid

: 1421333-25-6
(1S,2S)-2-[4-(methylcarbamoyl)benzyl]-2,3-dihydro-1H,1'H-2,2'-biinden-1-yl L-leucinate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; dichloromethane; ethyl acetate / 12 h / 20 °C

2: dicyclohexyl-carbodiimide; dmap / ethyl acetate / 12 h / 20 °C

3: dimethyl amine / tetrahydrofuran / 1 h / 0 - 20 °C

With dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; dimethyl amine; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 1421333-02-9
4-{[(1'S,2'S)-1'-hydroxy-1',3'-dihydro-1H,2'H-2,2'-biinden-2'-yl]methyl}-N-methylbenzamide

: 1421333-25-6
(1S,2S)-2-[4-(methylcarbamoyl)benzyl]-2,3-dihydro-1H,1'H-2,2'-biinden-1-yl L-leucinate

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; dmap / ethyl acetate / 12 h / 20 °C

2: dimethyl amine / tetrahydrofuran / 1 h / 0 - 20 °C

With dmap; dimethyl amine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate;