Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester
CAS No.:133227-81-3
Molecular Formula:C₁₈H₁₈Cl₂N₂O₇S
Molecular Weight:477.322
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester

Suppliers and Price of Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester

There total 1 articles about Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 56-75-7,85666-84-8
chloramphenicol

: 98-59-9
p-toluenesulfonyl chloride

: 133227-81-3
Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester

Guidance literature:: With pyridine; for 2h; Ambient temperature;
DOI:10.1021/ja00128a006

Reference yield: 17.0%

: 133227-81-3
Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester

: 21735-83-1
dichloroacetic acid-[(1R,2R)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide]

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2.3h;
DOI:10.1021/ja00128a006

Reference yield:

: 133227-81-3
Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester

: 165063-82-1
[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 17 percent / LiAlH₄ / tetrahydrofuran / 2.3 h / 0 - 20 °C

2: 74 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / 4.5 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00128a006