tert-butyl ([(4-acetylphenyl)acetyl]{2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]ethyl}amino)acetate

Base Information

Chemical Name:tert-butyl ([(4-acetylphenyl)acetyl]{2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]ethyl}amino)acetate
CAS No.:878556-00-4
Molecular Formula:C₃₃H₃₆N₂O₆
Molecular Weight:556.659
Hs Code.:

Synonyms:tert-butyl ([(4-acetylphenyl)acetyl]{2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]ethyl}amino)acetate

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Chemical Property of tert-butyl ([(4-acetylphenyl)acetyl]{2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]ethyl}amino)acetate

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Technology Process of tert-butyl ([(4-acetylphenyl)acetyl]{2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]ethyl}amino)acetate

There total 3 articles about tert-butyl ([(4-acetylphenyl)acetyl]{2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]ethyl}amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51229-51-7
4-acetylbenzyl bromide

: 878556-00-4
tert-butyl ([(4-acetylphenyl)acetyl]{2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]ethyl}amino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / dioxane; H₂O / 2 h / 90 °C

2: 47 percent / aq. acetic acid; sulfuric acid / 1.5 h / 100 °C

3: 97 percent / TBTU; HOBt; Et₃N / dimethylformamide / 1.33 h / 20 °C

With sulfuric acid; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja056358i

Reference yield:

: 10266-42-9
2-(4-acetylphenyl)acetonitrile

: 878556-00-4
tert-butyl ([(4-acetylphenyl)acetyl]{2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]ethyl}amino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / aq. acetic acid; sulfuric acid / 1.5 h / 100 °C

2: 97 percent / TBTU; HOBt; Et₃N / dimethylformamide / 1.33 h / 20 °C

With sulfuric acid; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ja056358i

Reference yield:

: 122-00-9
para-methylacetophenone

: 878556-00-4
tert-butyl ([(4-acetylphenyl)acetyl]{2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]ethyl}amino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / NBS; AIBN / acetonitrile / 1.5 h / 90 °C

2: 67 percent / dioxane; H₂O / 2 h / 90 °C

3: 47 percent / aq. acetic acid; sulfuric acid / 1.5 h / 100 °C

4: 97 percent / TBTU; HOBt; Et₃N / dimethylformamide / 1.33 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile; 1: Wohl-Ziegler bromination;
DOI:10.1021/ja056358i