4,7-dihydro-3-(2,4,6-trifluorophenoxy)methyl-5-methoxy-2-methylbenzofuran-4,7-dione

Base Information

Chemical Name:4,7-dihydro-3-(2,4,6-trifluorophenoxy)methyl-5-methoxy-2-methylbenzofuran-4,7-dione
CAS No.:1596355-62-2
Molecular Formula:C₁₇H₁₁F₃O₅
Molecular Weight:352.267
Hs Code.:

Synonyms:4,7-dihydro-3-(2,4,6-trifluorophenoxy)methyl-5-methoxy-2-methylbenzofuran-4,7-dione

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Chemical Property of 4,7-dihydro-3-(2,4,6-trifluorophenoxy)methyl-5-methoxy-2-methylbenzofuran-4,7-dione

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Technology Process of 4,7-dihydro-3-(2,4,6-trifluorophenoxy)methyl-5-methoxy-2-methylbenzofuran-4,7-dione

There total 4 articles about 4,7-dihydro-3-(2,4,6-trifluorophenoxy)methyl-5-methoxy-2-methylbenzofuran-4,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 2268-17-9
2,4,6-trifluorophenol

: 1596355-71-3
3-chloromethyl-5-methoxy-2-methylbenzofuran-4,7-dione

: 1596355-62-2
4,7-dihydro-3-(2,4,6-trifluorophenoxy)methyl-5-methoxy-2-methylbenzofuran-4,7-dione

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1039/c3ob42258e

Reference yield:

: 1596355-49-5
methyl 4,7-dihydro-5-methoxy-2-methyl-4,7-dioxobenzofuran-3-carboxylate

: 1596355-62-2
4,7-dihydro-3-(2,4,6-trifluorophenoxy)methyl-5-methoxy-2-methylbenzofuran-4,7-dione

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c3ob42258e

Reference yield:

: 1596355-57-5
4,7-dihydro-3-hydroxymethyl-5-methoxy-2-methylbenzofuran-4,7-dione

: 1596355-62-2
4,7-dihydro-3-(2,4,6-trifluorophenoxy)methyl-5-methoxy-2-methylbenzofuran-4,7-dione

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / 20 °C / Inert atmosphere

With thionyl chloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c3ob42258e