2-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)acetic acid

Base Information

• Chemical Name: 2-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)acetic acid
• CAS No.: 215181-78-5
• Molecular Formula: C₁₈H₁₇N₃O₄
• Molecular Weight: 339.351
• Mol file: 215181-78-5.mol

Synonyms:2-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)acetic acid

Chemical Property of 2-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)acetic acid

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)acetic acid

There total 1 articles about 2-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-aminophenylacetic acid (1197-55-3) + 6,7-dimethoxy-4-chloroquinazoline (13790-39-1) → 2-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)acetic acid (215181-78-5)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; at 80 ℃; for 2h;

DOI:10.1016/j.bmcl.2011.11.019

Reference yield: 70.0%

1‐(propan‐2‐yl)‐1H‐pyrazol‐4‐amine (97421-16-4) + 2-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)acetic acid (215181-78-5) → C24H26N6O3 (1355221-49-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2012.03.074

Reference yield:

2-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)acetic acid (215181-78-5) + m-Anisidine (536-90-3,918666-97-4) → C25H24N4O4 (1355221-26-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.11.019

upstream raw materials:

4-aminophenylacetic acid

6,7-dimethoxy-4-chloroquinazoline

Downstream raw materials:

C₂₄H₂₆N₆O₃

C₂₅H₂₄N₄O₄