1-[(8S,9S,10R,13S,14S,17S)-3-(5-Benzoyl-2-hydroxy-phenylethynyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone

Base Information

Chemical Name:1-[(8S,9S,10R,13S,14S,17S)-3-(5-Benzoyl-2-hydroxy-phenylethynyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone
CAS No.:183589-19-7
Molecular Formula:C₃₆H₃₈O₃
Molecular Weight:518.696
Hs Code.:

1-[(8S,9S,10R,13S,14S,17S)-3-(5-Benzoyl-2-hydroxy-phenylethynyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone

Synonyms:1-[(8S,9S,10R,13S,14S,17S)-3-(5-Benzoyl-2-hydroxy-phenylethynyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone

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Chemical Property of 1-[(8S,9S,10R,13S,14S,17S)-3-(5-Benzoyl-2-hydroxy-phenylethynyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone

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Technology Process of 1-[(8S,9S,10R,13S,14S,17S)-3-(5-Benzoyl-2-hydroxy-phenylethynyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone

There total 5 articles about 1-[(8S,9S,10R,13S,14S,17S)-3-(5-Benzoyl-2-hydroxy-phenylethynyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 183589-12-0
Acetic acid 2-((8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ylethynyl)-4-benzoyl-phenyl ester

: 183589-19-7
1-[(8S,9S,10R,13S,14S,17S)-3-(5-Benzoyl-2-hydroxy-phenylethynyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone

Guidance literature:: With hydrogenchloride; In water; acetone; at 60 ℃; for 24h;
DOI:10.1021/jo961051a

Reference yield:

: 95667-43-9
17β-Acetylandrosta-3,5-dien-3-yl triflate

: 183589-19-7
1-[(8S,9S,10R,13S,14S,17S)-3-(5-Benzoyl-2-hydroxy-phenylethynyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent

2: 94 percent / KF / methanol / 6 h / Ambient temperature

3: 52 percent / Et₃N, Pd(OAc)2(PPh₃)2 / dimethylformamide / 4 h / 80 °C

4: 40 percent / HCl / H₂O; acetone / 24 h / 60 °C

With hydrogenchloride; potassium fluoride; bis(triphenylphosphine) palladium (Il) acetate; triethylamine; In methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo961051a

Reference yield:

: Acetic acid 4-benzoyl-2-iodo-phenyl ester

: 183589-19-7
1-[(8S,9S,10R,13S,14S,17S)-3-(5-Benzoyl-2-hydroxy-phenylethynyl)-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / Et₃N, Pd(OAc)2(PPh₃)2 / dimethylformamide / 4 h / 80 °C

2: 40 percent / HCl / H₂O; acetone / 24 h / 60 °C

With hydrogenchloride; bis(triphenylphosphine) palladium (Il) acetate; triethylamine; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo961051a