2-(2-chloro-4-fluorophenyl)-3-methylpyridine

Base Information

• Chemical Name: 2-(2-chloro-4-fluorophenyl)-3-methylpyridine
• CAS No.: 1429740-63-5
• Molecular Formula: C₁₂H₉ClFN
• Molecular Weight: 221.662
• Mol file: 1429740-63-5.mol

Synonyms:2-(2-chloro-4-fluorophenyl)-3-methylpyridine

Chemical Property of 2-(2-chloro-4-fluorophenyl)-3-methylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-chloro-4-fluorophenyl)-3-methylpyridine

There total 3 articles about 2-(2-chloro-4-fluorophenyl)-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-(4-fluorophenyl)-3-methylpyridine (101419-76-5) → 2-(2-chloro-4-fluorophenyl)-3-methylpyridine (1429740-63-5)

Guidance literature:

With copper(II) nitrate trihydrate; oxygen; acetic acid; lithium chloride; at 150 ℃; for 12h; under 760.051 Torr; Sealed tube;

DOI:10.1039/c3ob40185e

Reference yield:

4-fluoroboronic acid (1765-93-1) → 2-(2-chloro-4-fluorophenyl)-3-methylpyridine (1429740-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; potassium phosphate tribasic heptahydrate; oxygen / isopropyl alcohol / 80 °C

2: oxygen; copper(II) nitrate trihydrate; lithium chloride; acetic acid / 12 h / 150 °C / 760.05 Torr / Sealed tube

With copper(II) nitrate trihydrate; potassium phosphate tribasic heptahydrate; oxygen; palladium diacetate; acetic acid; lithium chloride; In isopropyl alcohol; 1: |Suzuki Coupling;

DOI:10.1039/c3ob40185e

Reference yield:

2-bromo-3-picoline (3430-17-9) → 2-(2-chloro-4-fluorophenyl)-3-methylpyridine (1429740-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; potassium phosphate tribasic heptahydrate; oxygen / isopropyl alcohol / 80 °C

2: oxygen; copper(II) nitrate trihydrate; lithium chloride; acetic acid / 12 h / 150 °C / 760.05 Torr / Sealed tube

With copper(II) nitrate trihydrate; potassium phosphate tribasic heptahydrate; oxygen; palladium diacetate; acetic acid; lithium chloride; In isopropyl alcohol; 1: |Suzuki Coupling;

DOI:10.1039/c3ob40185e

upstream raw materials:

2-(4-fluorophenyl)-3-methylpyridine

4-fluoroboronic acid

2-bromo-3-picoline