Technology Process of 1-methyl-4-(2,4,6-trichloro-phenyl)-butylamine
There total 6 articles about 1-methyl-4-(2,4,6-trichloro-phenyl)-butylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(2,4,6-trichloro-phenyl)-pentan-2-one;
With
ammonium acetate;
In
methanol;
at 20 ℃;
for 0.5h;
With
sodium cyanoborohydride;
In
methanol;
at 0 - 20 ℃;
for 5h;
With
hydrogenchloride; water;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / chloroform / 3.25 h / 0 - 20 °C
2.1: ethanol; water / 4 h / 20 °C / Reflux
3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 3.5 h / -70 °C
3.2: 0.5 h / -40 - 20 °C
4.1: triethylammonium formate / 0.17 h / 20 °C
4.2: 3.33 h / 120 °C
5.1: diethyl ether / 3.25 h / 0 - 20 °C
6.1: ammonium acetate / methanol / 0.5 h / 20 °C
6.2: 5 h / 0 - 20 °C
With
thionyl chloride; ammonium acetate; diisobutylaluminium hydride; triethylammonium formate;
N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; chloroform; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylammonium formate / 0.17 h / 20 °C
1.2: 3.33 h / 120 °C
2.1: diethyl ether / 3.25 h / 0 - 20 °C
3.1: ammonium acetate / methanol / 0.5 h / 20 °C
3.2: 5 h / 0 - 20 °C
With
ammonium acetate; triethylammonium formate;
In
methanol; diethyl ether;
