(alphaR)-N-[3-[3-(Difluoromethyl)phenyl]propyl]-alpha-methyl-1-naphthalenemethanamine

Base Information

• Chemical Name: (alphaR)-N-[3-[3-(Difluoromethyl)phenyl]propyl]-alpha-methyl-1-naphthalenemethanamine
• CAS No.: 1025064-41-8
• Molecular Formula: C₂₂H₂₃F₂N
• Molecular Weight: 339.428
• Mol file: 1025064-41-8.mol

Synonyms:[3-(3-difluoromethyl-phenyl)-propyl]-((R)-1-naphthalen-1-yl-ethyl)-amine

Chemical Property of (alphaR)-N-[3-[3-(Difluoromethyl)phenyl]propyl]-alpha-methyl-1-naphthalenemethanamine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(αR)-N-[3-[3-(Difluoromethyl)phenyl]propyl]-α-methyl-1-naphthalenemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (αR)-N-[3-[3-(Difluoromethyl)phenyl]propyl]-α-methyl-1-naphthalenemethanamine is an impurity of Cinacalcet (C441800); an oral calcimimetic agent that modulates the calcium-sensing receptor, reduces parathyroid hormone (PHT) secretion, and lowers serum calcium and phosphorus concentrations in patients with endstage renal disease (ESRD) and secondary hyperparathyroidism (HPT).

Technology Process of (alphaR)-N-[3-[3-(Difluoromethyl)phenyl]propyl]-alpha-methyl-1-naphthalenemethanamine

There total 1 articles about (alphaR)-N-[3-[3-(Difluoromethyl)phenyl]propyl]-alpha-methyl-1-naphthalenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide (1005450-55-4,955371-05-8) → [3-(3-difluoromethyl-phenyl)-propyl]-((R)-1-naphthalen-1-yl-ethyl)-amine (1025064-41-8)

Guidance literature:

(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide; With lithium aluminium tetrahydride; In tetrahydrofuran; at 40 - 65 ℃; for 50h;

With ethyl acetate; In tetrahydrofuran; at 5 ℃; for 0.5h;

With water; In tetrahydrofuran; at 28 ℃; for 0.5h; Product distribution / selectivity;

upstream raw materials:

(R)‐N‐(1‐(naphthalen‐1‐yl)ethyl)‐3‐(3‐trifluoromethylphenyl)propanamide

Refernces