N-[(2-hydroxyphenyl)methylene]-L-valyl-N-butyl-L-phenylalaninamide

Base Information

• Chemical Name: N-[(2-hydroxyphenyl)methylene]-L-valyl-N-butyl-L-phenylalaninamide
• CAS No.: 329324-39-2
• Molecular Formula: C₂₅H₃₃N₃O₃
• Molecular Weight: 423.555
• Mol file: 329324-39-2.mol

Synonyms:N-[(2-hydroxyphenyl)methylene]-L-valyl-N-butyl-L-phenylalaninamide

Chemical Property of N-[(2-hydroxyphenyl)methylene]-L-valyl-N-butyl-L-phenylalaninamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(2-hydroxyphenyl)methylene]-L-valyl-N-butyl-L-phenylalaninamide

There total 7 articles about N-[(2-hydroxyphenyl)methylene]-L-valyl-N-butyl-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-butylcarbamoyl-2-phenyl-ethyl-carbamic acid tert butyl ester (112670-44-7) → N-[(2-hydroxyphenyl)methylene]-L-valyl-N-butyl-L-phenylalaninamide (329324-39-2)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl / dioxane / 1 h / 0 - 22 °C

2: 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride; N-hydroxybenzotriazole; triethylamine / CH₂Cl₂ / 12 h / 0 - 22 °C

3: HCl / dioxane / 1 h / 0 - 22 °C

4: 4.8 g / MgSO₄ / CH₂Cl₂ / 12 h

With hydrogenchloride; magnesium sulfate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ja003747y

Reference yield:

[(S)-1-((S)-1-Butylcarbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester (329324-40-5) → N-[(2-hydroxyphenyl)methylene]-L-valyl-N-butyl-L-phenylalaninamide (329324-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / dioxane / 1 h / 0 - 22 °C

2: 4.8 g / MgSO₄ / CH₂Cl₂ / 12 h

With hydrogenchloride; magnesium sulfate; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ja003747y

Reference yield:

salicylaldehyde (90-02-8) + H2N-L-Val-L-Phe-Bu (264887-19-6) → N-[(2-hydroxyphenyl)methylene]-L-valyl-N-butyl-L-phenylalaninamide (329324-39-2)

Guidance literature:

With magnesium sulfate; In dichloromethane; for 12h;

DOI:10.1021/ja0118744 DOI:10.1021/ja003747y

upstream raw materials:

salicylaldehyde

H₂N-L-Val-L-Phe-Bu

1-butylcarbamoyl-2-phenyl-ethyl-carbamic acid tert butyl ester

[(S)-1-((S)-1-Butylcarbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester