N-(5-chloro-2-methoxyphenyl)-1-<(4-chlorophenyl)methyl>-4-piperidinecarboxamide

Base Information

• Chemical Name: N-(5-chloro-2-methoxyphenyl)-1-<(4-chlorophenyl)methyl>-4-piperidinecarboxamide
• CAS No.: 69082-61-7
• Molecular Formula: C₂₀H₂₂Cl₂N₂O₂
• Molecular Weight: 393.313

Synonyms:N-(5-chloro-2-methoxyphenyl)-1-<(4-chlorophenyl)methyl>-4-piperidinecarboxamide

Chemical Property of N-(5-chloro-2-methoxyphenyl)-1-<(4-chlorophenyl)methyl>-4-piperidinecarboxamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(5-chloro-2-methoxyphenyl)-1-<(4-chlorophenyl)methyl>-4-piperidinecarboxamide

There total 3 articles about N-(5-chloro-2-methoxyphenyl)-1-<(4-chlorophenyl)methyl>-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Chloro-2-(4-pyridinecarboxamido)anisole hydrochloride (69082-74-2) → N-(5-chloro-2-methoxyphenyl)-1-<(4-chlorophenyl)methyl>-4-piperidinecarboxamide (69082-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / H₂ / PtO₂ / ethanol / 6 h / 70 °C / 15514.4 Torr

2: K₂CO₃ / dimethylformamide / 17 h / Ambient temperature

With hydrogen; potassium carbonate; platinum(IV) oxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00366a017

Reference yield:

N-(5-chloro-2-methoxyphenyl)-4-piperidinecarboxamide (69082-73-1) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → N-(5-chloro-2-methoxyphenyl)-1-<(4-chlorophenyl)methyl>-4-piperidinecarboxamide (69082-61-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 17h; Ambient temperature;

DOI:10.1021/jm00366a017

Reference yield:

→ N-(5-chloro-2-methoxyphenyl)-1-<(4-chlorophenyl)methyl>-4-piperidinecarboxamide (69082-61-7)

Guidance literature:

upstream raw materials:

N-(5-chloro-2-methoxyphenyl)-4-piperidinecarboxamide

1-Chloro-4-(chloromethyl)benzene

4-Chloro-2-(4-pyridinecarboxamido)anisole hydrochloride

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