tert-butyl 2-(((1s,4s)-4-((3-cyclopropyl-4-iodo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate

Base Information

Chemical Name:tert-butyl 2-(((1s,4s)-4-((3-cyclopropyl-4-iodo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate
CAS No.:1231310-08-9
Molecular Formula:C₂₆H₃₅IN₂O₃
Molecular Weight:550.48
Hs Code.:

Synonyms:tert-butyl 2-(((1s,4s)-4-((3-cyclopropyl-4-iodo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate

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Chemical Property of tert-butyl 2-(((1s,4s)-4-((3-cyclopropyl-4-iodo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate

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Technology Process of tert-butyl 2-(((1s,4s)-4-((3-cyclopropyl-4-iodo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate

There total 2 articles about tert-butyl 2-(((1s,4s)-4-((3-cyclopropyl-4-iodo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1231308-06-7
5-cyclopropyl-4-iodo-3-phenyl-1H-pyrazole

: 1231307-72-4
tert-butyl 2-(((1s,4s)-4-(tosyloxymethyl)cyclohexyl)methoxy)acetate

: 1231310-08-9
tert-butyl 2-(((1s,4s)-4-((3-cyclopropyl-4-iodo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: 5-cyclopropyl-4-iodo-3-phenyl-1H-pyrazole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

tert-butyl 2-(((1s,4s)-4-(tosyloxymethyl)cyclohexyl)methoxy)acetate; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 16h;

Reference yield:

: 1231308-06-7
5-cyclopropyl-4-iodo-3-phenyl-1H-pyrazole

: 1231307-72-4
tert-butyl 2-(((1s,4s)-4-(tosyloxymethyl)cyclohexyl)methoxy)acetate

: 1231310-08-9
tert-butyl 2-(((1s,4s)-4-((3-cyclopropyl-4-iodo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate

: 1231308-09-0
tert-butyl 2-(((1s,4s)-4-((5-cyclopropyl-4-iodo-3-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: 5-cyclopropyl-4-iodo-3-phenyl-1H-pyrazole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

tert-butyl 2-(((1s,4s)-4-(tosyloxymethyl)cyclohexyl)methoxy)acetate; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 16h;

Reference yield:

: 1231310-08-9
tert-butyl 2-(((1s,4s)-4-((3-cyclopropyl-4-iodo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate

: 98-80-6
phenylboronic acid

: 1231304-28-1
2-(((1s,4s)-4-((3-cyclopropyl-4,5-diphenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetic acid

Guidance literature:: tert-butyl 2-(((1s,4s)-4-((3-cyclopropyl-4-iodo-5-phenyl-1H-pyrazol-1-yl)methyl)cyclohexyl)methoxy)acetate; phenylboronic acid; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 150 ℃; for 4h; Microwave irradiation;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 10h;