3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-fluorophenyl)propanoic acid

Base Information

Chemical Name:3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-fluorophenyl)propanoic acid
CAS No.:1001124-54-4
Molecular Formula:C₁₇H₂₄FNO₄
Molecular Weight:325.38
Hs Code.:

Synonyms:3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-fluorophenyl)propanoic acid

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Chemical Property of 3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-fluorophenyl)propanoic acid

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Technology Process of 3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-fluorophenyl)propanoic acid

There total 8 articles about 3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-fluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.06%

: 1001124-53-3
methyl 2-(4-fluorophenyl)-3-(isopropylamino)propanoate

: 24424-99-5
di-tert-butyl dicarbonate

: 1001124-54-4
3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-fluorophenyl)propanoic acid

Guidance literature:: methyl 2-(4-fluorophenyl)-3-(isopropylamino)propanoate; di-tert-butyl dicarbonate; In dichloromethane; at 20 ℃;

With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; water; pH=2 - 3;

Reference yield: 14.0%

: C₁₉H₂₈FNO₄

: 1001124-54-4
3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-fluorophenyl)propanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 60 ℃;
DOI:10.1016/j.ejmech.2020.112076

Reference yield:

: 34837-84-8
4-fluorobenzeneacetic acid methyl ester

: 1001124-54-4
3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-fluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / dimethyl sulfoxide / 20 °C

2.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 48 h / 0 - 20 °C

3.1: tetrahydrofuran / 2 h / 20 °C

4.1: dichloromethane / 20 °C

4.2: 20 °C

4.3: pH 2 - 3

With sodium methylate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;