Technology Process of 1-hydroxy-2,3-dimethoxy-5-(3',4',5'-trimethoxyphenyl)benzocyclohept-5-ene
There total 8 articles about 1-hydroxy-2,3-dimethoxy-5-(3',4',5'-trimethoxyphenyl)benzocyclohept-5-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-tosyloxy-2,3-dimethoxy-5-(3',4',5'-trimethoxyphenyl)benzocyclohept-5-ene;
With
methanol; sodium hydroxide;
at 100 ℃;
for 1h;
Microwave irradiation;
Sealed tube;
With
hydrogenchloride;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.25 h / -50 - 20 °C / Inert atmosphere
2.2: -78 - 20 °C
3.1: hydrogen / palladium 10% on activated carbon / ethanol; methanol / 12 h
4.1: methanesulfonic acid; phosphorus pentoxide / 12 h / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C / Inert atmosphere
5.2: -78 - 20 °C
5.3: 20 °C
6.1: acetic acid / water / 12 h / 180 °C
7.1: sodium hydroxide; methanol / 1 h / 100 °C / Microwave irradiation; Sealed tube
With
methanol; n-butyllithium; methanesulfonic acid; phosphorus pentoxide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; hexanes; ethanol; water; N,N-dimethyl-formamide;
2.1: Wittig Reaction;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: boron trichloride / dichloromethane / 5 h / 0 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.25 h / -50 - 20 °C / Inert atmosphere
3.2: -78 - 20 °C
4.1: hydrogen / palladium 10% on activated carbon / ethanol; methanol / 12 h
5.1: methanesulfonic acid; phosphorus pentoxide / 12 h / Inert atmosphere
6.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C / Inert atmosphere
6.2: -78 - 20 °C
6.3: 20 °C
7.1: acetic acid / water / 12 h / 180 °C
8.1: sodium hydroxide; methanol / 1 h / 100 °C / Microwave irradiation; Sealed tube
With
methanol; n-butyllithium; methanesulfonic acid; phosphorus pentoxide; hydrogen; boron trichloride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; hexanes; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
3.1: Wittig Reaction;
