Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester

Base Information

Chemical Name:Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester
CAS No.:288861-54-1
Molecular Formula:C₆₆H₆₇F₃NO₁₆P₃
Molecular Weight:1280.17
Hs Code.:

Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester

Synonyms:Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester

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Chemical Property of Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester

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Technology Process of Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester

There total 8 articles about Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Phosphorous acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphanyloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester

: 288861-54-1
Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 - 20 ℃; for 0.5h;
DOI:10.1039/b002312o

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 288861-54-1
Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-tetrazole / CH₂Cl₂ / 1 h / 20 °C

2: MCPBA / CH₂Cl₂ / 0.5 h / -78 - 20 °C

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1: Substitution / 2: Oxidation;
DOI:10.1039/b002312o

Reference yield:

: 221462-15-3
(2'S,3'S)-1D-3,6-di-O-benzyl-4,5-O-(2',3'-dimethoxybutane-2',3'-diyl)-myo-inositol

: 288861-54-1
Phosphoric acid dibenzyl ester (1R,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-cyclohexyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: Bu₂SnO; molecular sieves 4 Angstroem / methanol / 16 h / Heating

1.2: 84 percent / CsF / dimethylformamide / 5 h / 50 °C

2.1: 83 percent / NaH / acetonitrile / 21 h / -20 - 20 °C

3.1: LAH / tetrahydrofuran / 1 h / 20 °C

4.1: tetrahydrofuran / 20 °C

5.1: H₂O; TFA / CH₂Cl₂ / 0.5 h / 20 °C

6.1: 1H-tetrazole / CH₂Cl₂ / 1 h / 20 °C

7.1: MCPBA / CH₂Cl₂ / 0.5 h / -78 - 20 °C

With 1H-tetrazole; lithium aluminium tetrahydride; 4 A molecular sieve; water; sodium hydride; di(n-butyl)tin oxide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 1.1: Cyclization / 1.2: Ring cleavage / 2.1: Alkylation / 3.1: Reduction / 4.1: Acylation / 5.1: Hydrolysis / 6.1: Substitution / 7.1: Oxidation;
DOI:10.1039/b002312o